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Weber, K.S.* ; Schlesinger, S.* ; Lang, A.* ; Goletzke, J.* ; Cara Övermöhle,* ; Strathmann, E.A.* ; Straßburger, K.* ; Singh, N.O.* ; Zaharia, O.P.* ; Trenkamp, S.* ; Wagner, R.* ; Lieb, W.* ; Buyken, A.E.* ; Roden, M.* ; Herder, C.* ; Al-Hasani, H.* ; Belgardt, B.* ; Bönhof, G.* ; Geerling, G.* ; Icks, A.* ; Jandeleit-Dahm, K.* ; Kuß, O.* ; Lammert, E.* ; Schlesinger, S.* ; Schrauwen-Hinderling, V.* ; Szendroedi, J. ; Trenkamp, S.*

Differential associations of dietary patterns with estimated 10-year cardiovascular risk in diabetes subtypes.

Sci. Rep. 16:20783 (2026)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Diet impacts cardiovascular disease risk, but the association across diabetes subtypes is unclear. We thus aimed to assess the association between dietary factors and estimated 10-year cardiovascular disease risk across diabetes subtypes in the German Diabetes Study (GDS). Participants with recent-onset diabetes and from the 5-year follow-up examination were combined (n=635, mean age 47.5±12.9 years, 60% male) and classified into diabetes subtypes. Subtypes with prevalence >10% were included in cross-sectional analyses: severe autoimmune diabetes (39%), mild obesity-related diabetes (31%), and mild age-related diabetes (30%). Carbohydrate quality parameters and adherence to dietary patterns were assessed from food frequency questionnaires. Differences in associations between these dietary factors and 10-year cardiovascular risk estimated by SCORE2-Diabetes across subtypes were examined using multivariable-adjusted linear regression models including an interaction term. In people with severe autoimmune diabetes, the overall and the healthful plant-based diet index were associated with lower estimated 10-year cardiovascular risk (ß [95% CI] -6.8 [-12.1; -1.2] and -8.8% [-14.0; -3.2] per 1-standard deviation increases, respectively), while these associations were not evident among the remaining two subtypes (p-value for interaction between subtypes <0.05). Our findings suggest subtype-specific associations of plant-based dietary patterns with estimated cardiovascular risk, warranting further research from longitudinal and intervention studies. Trial registration: Clinicaltrials.gov: NCT01055093
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Publication type Article: Journal article
Document type Scientific Article
Keywords Diabetes Mellitus ; Disease ; Type 2 Diabetes ; Confounding ; Obesity ; Epidemiology ; Type 1 Diabetes ; National Health And Nutrition Examination Survey ; Linear Regression; Glycemic Index; Disease; Participants; Metaanalysis; Adherence; Subgroups; Validity
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Journal Scientific Reports
Quellenangaben Volume: 16, Issue: 1, Pages: , Article Number: 20783 Supplement: ,
Publisher Springer
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
Grants Universittsklinikum Schleswig-Holstein - Campus Kiel (6509)