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Arnold, N.* ; Magnussen, C.* ; Weimann, J.* ; Goßling, A.* ; Brunner, F.J.* ; Ferrario, M.* ; Brambilla, P.* ; Cesana, G.* ; Leoni, V.* ; Palmieri, L.* ; Donfrancesco, C.* ; Padró, T.* ; Andersson, J.* ; Jousilahti, P.* ; Ojeda, F.* ; Zeller, T.* ; Linneberg, A.* ; Söderberg, S.* ; Iacoviello, L.* ; Gianfagna, F.* ; Sans, S.* ; Veronesi, G.* ; Thorand, B. ; Peters, A. ; Tunstall-Pedoe, H.* ; Kee, F.* ; Salomaa, V.* ; Schnabel, R.B.* ; Kuulasmaa, K.* ; Blankenberg, S.* ; Twerenbold, R.* ; Köenig, W.*

Incident coronary heart disease, residual risk and traditional cardiovascular risk factors in the community: The role of the lipid-inflammatory axis.

Am. J. Prev. Cardiol.:101812 (2026)
Postprint Research data DOI
Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Background and aims: Coronary heart disease (CHD) occurs even in individuals classified as “low-risk” by traditional cardiovascular risk factors (CVRFs). We aimed to investigate whether the combinations of high-sensitivity C-reactive protein (hsCRP), lipoprotein (a) (Lp(a)), or triglycerides (TGs) would modulate relative and absolute CHD risk within a low-risk population. Methods: A total of 63,740 individuals free of CHD at baseline were included. Participants were stratified according to CVRF burden at baseline: 0/1 vs. ≥2 CVRFs. Biomarkers were analyzed dichotomously: hsCRP (
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Publication type Article: Journal article
Document type Scientific Article
Keywords Coronary Heart Disease ; Residual Risk ; Risk Factor ; Atherosclerotic Cardiovascular Disease ; Framingham Risk Score ; Disease ; Absolute Risk Reduction ; Risk Assessment
ISSN (print) / ISBN 2666-6677
e-ISSN 2666-6677
Journal American Journal of Preventive Cardiology
Quellenangaben Volume: , Issue: , Pages: , Article Number: 101812 Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)