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Sujana, C. ; Seissler, J.* ; Jordan, J.* ; Rathmann, W.* ; Koenig, W.* ; Roden, M.* ; Mansmann, U.* ; Herder, C.* ; Peters, A. ; Thorand, B. ; Then, C.*

Associations of cardiac stress biomarkers with incident type 2 diabetes and changes in glucose metabolism: KORA F4/FF4 study.

Cardiovasc. Diabetol. 19 (2020)

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Background High N-terminal pro-brain-type natriuretic peptide levels have been associated with a lower risk of type 2 diabetes mellitus (T2D). However, less is known about other cardiac stress biomarkers in this context. Here we evaluated the association of mid-regional pro-atrial natriuretic peptide (MR-proANP), C-terminal pro-arginine vasopressin (copeptin), C-terminal pro-endothelin-1 (CT-proET-1) and mid-regional pro-adrenomedullin (MR-proADM) with incident T2D and changes in glucose metabolism. Methods We performed a prospective cohort study using data from the population-based KORA F4/FF4 study. 1773 participants (52.3% women) with MR-proANP measurements and 960 (52.7% women) with copeptin, CT-proET-1 and MR-proADM measurements were included. We examined associations of circulating plasma levels of MR-proANP, copeptin, CT-proET-1 and MR-proADM with incident T2D, the combined endpoint of incident prediabetes/T2D and with fasting and 2 h-glucose, fasting insulin, HOMA-IR, HOMA-B and HbA1c at follow-up. Logistic and linear regression models adjusted for age, sex, waist circumference, height, hypertension, total/HDL cholesterol ratio, triglycerides, smoking, physical activity and parental history of diabetes were used to compute effect estimates. Results During a median follow-up time of 6.4 years (25th and 75th percentiles: 6.0 and 6.6, respectively), 119 out of the 1773 participants and 72 out of the 960 participants developed T2D. MR-proANP was inversely associated with incident T2D (odds ratio [95% confidence interval]: 0.75 [0.58; 0.96] per 1-SD increase of log MR-proANP). Copeptin was positively associated with incident prediabetes/T2D (1.29 [1.02; 1.63] per 1-SD increase of log copeptin). Elevated levels of CT-proET-1 were associated with increased HOMA-B at follow-up, while elevated MR-proADM levels were associated with increased fasting insulin, HOMA-IR and HOMA-B at follow-up. These associations were independent of previously described diabetes risk factors. Conclusions High plasma concentrations of MR-proANP contributed to a lower risk of incident T2D, whereas high plasma concentrations of copeptin were associated with an increased risk of incident prediabetes/T2D. Furthermore, high plasma concentrations of CT-proET-1 and MR-proADM were associated with increased insulin resistance. Our study provides evidence that biomarkers implicated in cardiac stress are associated with incident T2D and changes in glucose metabolism.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Mr-proanp ; Copeptin ; Ct-proet-1 ; Mr-proadm ; Cardiac Stress Biomarkers ; Type 2 Diabetes ; Prediabetes ; Insulin Resistance ; Incidence ; Cohort Study; Atrial-natriuretic-peptide; Insulin-resistance; Plasma Copeptin; Heart-failure; Adrenomedullin; Risk; Secretion; Inflammation; Prevalence; Mellitus

ISSN (print) / ISBN 1475-2840

e-ISSN 1475-2840

Journal Cardiovascular Diabetology

Quellenangaben Volume: 19, Issue: 1

Publisher BioMed Central

Publishing Place Campus, 4 Crinan St, London N1 9xw, England

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology (EPI)

Grants Bundesministerium für Bildung und Forschung
Helmholtz Zentrum Munchen
Deutsche Forschungsgemeinschaft
Projekt DEAL
Helmholtz Zentrum Munchen - German Research Centre for Environmental Health
German Federal Ministry of Education and Research (BMBF)
State of Bavaria
Virtual Institute of Diabetes Research (Helmholtz Zentrum Munchen)
Ludwig-Maximilians-Universitat Munchen
German Diabetes Center (DDZ)
Federal Ministry of Health (Berlin, Germany)
Ministry of Culture and Science of the state North Rhine Westphalia (Dusseldorf, Germany)
Deutsche Diabetes Gesellschaft (DDG)
German Research Foundation (DFG)