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Sarfraz, I.* ; Wang, Y.* ; Shastry, A.* ; Teh, W.K.* ; Sokolov, A.* ; Herb, B.R.* ; Creasy, H.H.* ; Virshup, I. ; Dries, R.* ; Degatano, K.* ; Mahurkar, A.* ; Schnell, D.J.* ; Madrigal, P.* ; Hilton, J.* ; Gehlenborg, N.* ; Tickle, T.* ; Campbell, J.D.*

MAMS: Matrix and analysis metadata standards to facilitate harmonization and reproducibility of single-cell data.

Genome Biol. 25:205 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Many datasets are being produced by consortia that seek to characterize healthy and disease tissues at single-cell resolution. While biospecimen and experimental information is often captured, detailed metadata standards related to data matrices and analysis workflows are currently lacking. To address this, we develop the matrix and analysis metadata standards (MAMS) to serve as a resource for data centers, repositories, and tool developers. We define metadata fields for matrices and parameters commonly utilized in analytical workflows and developed the rmams package to extract MAMS from single-cell objects. Overall, MAMS promotes the harmonization, integration, and reproducibility of single-cell data across platforms.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 1474-760X
e-ISSN 1465-6906
Journal Genome Biology
Quellenangaben Volume: 25, Issue: 1, Pages: , Article Number: 205 Supplement: ,
Publisher BioMed Central
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)