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Lindgren, C.M.* ; Heid, I.M. ; Randall, J.C.* ; Lamina, C. ; Steinthorsdottir, V.* ; Qi, L.* ; Speliotes, E.K.* ; Thorleifsson, G.* ; Willer, C.J.* ; Herrera, B.M.* ; Jackson, A.U.* ; Lim, N.* ; Scheet, P.* ; Soranzo, N.* ; Amin, N.* ; Aulchenko, Y.S.* ; Chambers, J.C.* ; Drong, A.* ; Luan, J.A.* ; Lyon, H.N.* ; Rivadeneira, F.* ; Sanna, S.* ; Timpson, N.J.* ; Zillikens, M.C.* ; Zhao, J.H.* ; Almgren, P.* ; Bandinelli, S.* ; Bennett, A.J.* ; Bergman, R.N.* ; Bonnycastle, L.L.* ; Bumpstead, S.J.* ; Chanock, S.J.* ; Cherkas, L.* ; Chines, P.* ; Coin, L.* ; Cooper, C.* ; Crawford, G.* ; Döring, A.* ; Dominiczak, A.* ; Doney, A.S.* ; Ebrahim, S.* ; Elliott, P.* ; Erdos, M.R.* ; Estrada, K.* ; Ferrucci, L.* ; Fischer, G. ; Forouhi, N.G.* ; Gieger, C. ; Grallert, H. ; Groves, C.J.* ; Grundy, S.* ; Guiducci, C.* ; Hadley, D.* ; Hamsten, A.* ; Havulinna, A.S.* ; Hofman, A.* ; Holle, R. ; Holloway, J.W.* ; Illig, T. ; Isomaa, B.* ; Jacobs, L.C.* ; Jameson, K.* ; Jousilahti, P.* ; Karpe, F.* ; Kuusisto, J.* ; Laitinen, J.* ; Lathrop, G.M.* ; Lawlor, D.A.* ; Mangino, M.* ; McArdle, W.L.* ; Meitinger, T. ; Morken, M.A.* ; Morris, A.P.* ; Munroe, P.* ; Narisu, N.* ; Nordstrom, A.* ; Nordstrom, P.* ; Oostra, B.A.* ; Palmer, C.N.A.* ; Payne, F.* ; Peden, J.F.* ; Prokopenko, I.* ; Renström, F.* ; Ruokonen, A.* ; Salomaa, V.* ; Sandhu, M.S.* ; Scott, L.J.* ; Scuteri, A.* ; Silander, K.* ; Song, K.J.* ; Yuan, X.* ; Stringham, H.M.* ; Swift, A.J.* ; Tuomi, T.* ; Uda, M.* ; Vollenweider, P.* ; Waeber, G.* ; Wallace, C.* ; Walters, G.B.* ; Weedon, M.N.* ; Witteman, J.C.M.* ; Zhang, C.L.* ; Zhang, W.H.* ; Caulfield, M.J.* ; Collins, F.S.* ; Smith, G.D.* ; Day, I.N.M.* ; Franks, P.W.* ; Hattersley, A.T.* ; Hu, F.B.* ; Jarvelin, M.R.* ; Kong, A.* ; Kooner, J.S.* ; Laakso, M.* ; Lakatta, E.* ; Mooser, V.* ; Morris, A.D.* ; Peltonen, L.* ; Samani, N.J.* ; Spector, T.D.* ; Strachan, D.P.* ; Tanaka, T.* ; Tuomilehto, J.* ; Uitterlinden, A.G.* ; van Duijn, C.M.* ; Wareham, N.J.* ; Watkins, H.* ; Waterworth, D.M.* ; Boehnke, M.* ; Deloukas, P.* ; Groop, L.* ; Hunter, D.J.* ; Thorsteinsdottir, U.* ; Schlessinger, D.* ; Wichmann, H.-E. ; Frayling, T.M.* ; Abecasis, G.R.* ; Hirschhorn, J.N.* ; Loos, R.J.F.* ; Stefansson, K.* ; Mohlke, K.L.* ; Barroso, I.S.* ; McCarthy, M.I.*

Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution.

PLoS Genet. 5:e1000508 (2009)
Verlagsversion Volltext DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter waist circumference; adult obesity; fto gene; environmental-conditions; insulin-resistance; sequence variants; common variants; expression; imputation; height; FTO GENE; WAIST CIRCUMFERENCE; ADULT OBESITY; ENVIRONMENTAL-CONDITIONS; INSULIN-RESISTANCE; SEQUENCE VARIANTS; COMMON VARIANTS; EXPRESSION; IMPUTATION; HEIGHT
Sprache englisch
Veröffentlichungsjahr 2009
HGF-Berichtsjahr 0
ISSN (print) / ISBN 1553-7390
e-ISSN 1553-7404
Zeitschrift PLoS Genetics
Quellenangaben Band: 5, Heft: 6, Seiten: , Artikelnummer: e1000508 Supplement: ,
Verlag Public Library of Science (PLoS)
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)
Institute of Health Economics and Health Care Management (IGM)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies

30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-001
G-503900-004
G-500700-001
G-505300-002
PubMed ID 19557161
DOI 10.1371/journal.pgen.1000508
WOS ID 000268444600004
Scopus ID 67651236725
Erfassungsdatum 2009-09-03
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