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Burger, K. ; Eick, D.

Functional ribosome biogenesis is a prerequisite for p53 destabilization: Impact of chemotherapy on nucleolar functions and RNA metabolism.

Biol. Chem. 394, 1133-1143 (2013)
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The production and processing of ribosomal RNA is a complex and well-coordinated nucleolar process for ribosome biogenesis. Progress in understanding nucleolar structure and function has lead to the unexpected discovery of the nucleolus as a highly sensitive sensor of cellular stress and an important regulator of the tumor suppressor p53. Inhibition of ribosomal RNA metabolism has been shown to activate a signaling pathway for p53 induction. This review elucidates the potential of classical and recently developed chemotherapeutic drugs to stabilize p53 by inhibiting nucleolar functions.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Chemotherapy ; Kinase Inhibitor ; Ribosome Biogenesis ; Rrna Processing ; Tumor Suppressor P53; Chronic Lymphocytic-leukemia ; Polymerase-i-transcription ; Cyclin-dependent Kinases ; Human Cancer-cells ; Wild-type P53 ; Protein-synthesis ; Dna-damage ; Cytoplasmic Maturation ; Nuclear Accumulation ; Carcinoma Cells
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 1431-6730
e-ISSN 1437-4315
Zeitschrift Biological Chemistry
Quellenangaben Band: 394, Heft: 9, Seiten: 1133-1143 Artikelnummer: , Supplement: ,
Verlag de Gruyter
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-501490-001
PubMed ID 23640940
DOI 10.1515/hsz-2013-0153
WOS ID WOS:000322962000003
Scopus ID 84881532614
Erfassungsdatum 2013-09-06
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