PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Xie, W.* ; Wood, A.R.* ; Lyssenko, V.* ; Weedon, M.N.* ; Knowles, J.W.* ; Alkayyali, S.* ; Assimes, T.L.* ; Quertermous, T.* ; Abbasi, F.* ; Paananen, J.* ; Häring, H.-U. ; Hansen, T.* ; Pedersen, O.* ; Smith, U.* ; Laakso, M.* ; MAGIC Investigators (Gieger, C. ; Wichmann, H.-E. ; Grallert, H. ; Thorand, B. ; Illig, T. ; Meisinger, C.) ; DIAGRAM Consortium (Huth, C. ; Grallert, H. ; Meitinger, T. ; Gieger, C. ; Wichmann, H.-E. ; Illig, T. ; Thorand, B. ; Petersen, A.-K. ; Klopp, N.) ; Dekker, J.M.* ; Nolan, J.J.* ; Groop, L.* ; Ferrannini, E.* ; Adam, K.-P.* ; Gall, W.E.* ; Frayling, T.M.* ; Walker, M.*

Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.

Diabetes 62, 2141-2150 (2013)
Verlagsversion Volltext DOI PMC
Closed
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Circulating metabolites associated with insulin sensitivity may represent useful biomarkers, but their causal role in insulin sensitivity and diabetes is less certain. We previously identified novel metabolites correlated with insulin sensitivity measured by the hyperinsulinemic-euglycemic clamp. The top-ranking metabolites were in the glutathione and glycine biosynthesis pathways. We aimed to identify common genetic variants associated with metabolites in these pathways and test their role in insulin sensitivity and type 2 diabetes. With 1,004 nondiabetic individuals from the RISC study, we performed a genome-wide association study (GWAS) of 14 insulin sensitivity-related metabolites and one metabolite ratio. We replicated our results in the Botnia study (n = 342). We assessed the association of these variants with diabetes-related traits in GWAS meta-analyses (GENESIS [including RISC, EUGENE2, and Stanford], MAGIC, and DIAGRAM). We identified four associations with three metabolites-glycine (rs715 at CPS1), serine (rs478093 at PHGDH), and betaine (rs499368 at SLC6A12; rs17823642 at BHMT)-and one association signal with glycine-to-serine ratio (rs1107366 at ALDH1L1). There was no robust evidence for association between these variants and insulin resistance or diabetes. Genetic variants associated with genes in the glycine biosynthesis pathways do not provide consistent evidence for a role of glycine in diabetes-related traits.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
7.895
2.093
28
58
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Zeitschrift Diabetes
Quellenangaben Band: 62, Heft: 6, Seiten: 2141-2150 Artikelnummer: , Supplement: ,
Verlag American Diabetes Association
Verlagsort Alexandria, VA.
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Molecular Epidemiology (AME)
Institute of Epidemiology (EPI)
Institute of Experimental Genetics (IEG)
Institute of Genetic Epidemiology (IGE)
Institute of Human Genetics (IHG)
Institute of Diabetes Research and Metabolic Diseases (IDM)
POF Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
90000 - German Center for Diabetes Research
30201 - Metabolic Health
30202 - Environmental Health
30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504200-002
G-501900-401
G-521500-002
G-504100-001
G-500700-001
G-504000-002
G-503900-001
DOI 10.2337/db12-0876
PubMed ID 23378610
Erfassungsdatum 2013-11-06
[➜Korrektur melden]