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Ma, X. ; Prakash, J. ; Ruscitti, F.* ; Glasl, S. ; Stellari, F.F.* ; Villetti, G.* ; Ntziachristos, V.

Assessment of asthmatic inflammation using hybrid fluorescence molecular tomography-X-ray computed tomography.

J. Biomed. Opt. 21:15009 (2016)
Verlagsversion DOI PMC
Open Access Gold
Nuclear imaging plays a critical role in asthma research but is limited in its readings of biology due to the short-lived signals of radio-isotopes. We employed hybrid fluorescence molecular tomography (FMT) and x-ray computed tomography (XCT) for the assessment of asthmatic inflammation based on resolving cathepsin activity and matrix metalloproteinase activity in dust mite, ragweed, and Aspergillus species-challenged mice. The reconstructed multimodal fluorescence distribution showed good correspondence with ex vivo cryosection images and histological images, confirming FMT-XCT as an interesting alternative for asthma research.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Asthmatic Inflammation ; Dust Mite, Ragweed, And Aspergillus Species-challenged Mouse Model ; Fluorescence Molecular Tomography ; Multimodality Imaging ; X-ray Computed Tomography; Airway Inflammation; Mouse Models; Immunology; Contrast; Mice; Ct
Sprache
Veröffentlichungsjahr 2016
HGF-Berichtsjahr 2016
ISSN (print) / ISBN 1083-3668
e-ISSN 1560-2281
Zeitschrift Journal of Biomedical Optics
Quellenangaben Band: 21, Heft: 1, Seiten: , Artikelnummer: 15009 Supplement: ,
Verlag SPIE
Verlagsort Bellingham
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505500-001
DOI 10.1117/1.JBO.21.1.015009
WOS ID WOS:000380036500009
Scopus ID 84955515592
PubMed ID 26803669
Erfassungsdatum 2016-01-26
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