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Kolahian, S.* ; Fernandez, I.E. ; Eickelberg, O. ; Hartl, D.*

Immune mechanisms in pulmonary fibrosis.

Am. J. Respir. Cell Mol. Biol. 55, 309-322 (2016)
Verlagsversion Postprint DOI PMC
Open Access Green
Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis, represents a chronic and progressive disease with high mortality and limited therapeutic options. Excessive deposition of extracellular matrix proteins results in fibrotic remodeling, alveolar destruction and irreversible loss of lung function. Both innate and adaptive immune mechanisms contribute to fibrogenesis at several cellular and non-cellular levels. Here, we summarize and discuss the role of immune cells (T cells, neutrophils, macrophages and fibrocytes) and soluble mediators (cytokines and chemokines) involved in pulmonary fibrosis, pointing towards novel immune-based therapeutic strategies in the field.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter T Cells ; Fibrosis ; Immunity ; Lung ; Neutrophils; Epithelial-mesenchymal Transition; Growth-factor-beta; Muc5b Promoter Polymorphism; Human Lung Fibroblasts; Regulatory T-cells; Gamma-delta T; Bronchoalveolar Lavage Fluid; Tyrosine Kinase Inhibitor; Versus-host-disease; Tgf-beta
Sprache englisch
Veröffentlichungsjahr 2016
HGF-Berichtsjahr 2016
ISSN (print) / ISBN 1044-1549
e-ISSN 1535-4989
Zeitschrift American Journal of Respiratory Cell and Molecular Biology
Quellenangaben Band: 55, Heft: 3, Seiten: 309-322 Artikelnummer: , Supplement: ,
Verlag American Thoracic Society
Verlagsort New York
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Lung Research
PSP-Element(e) G-501600-001
G-505000-006
DOI 10.1165/rcmb.2016-0121TR
WOS ID WOS:000385984100003
PubMed ID 27149613
Erfassungsdatum 2016-05-09
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