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Reitmeir, P. ; Linkohr, B. ; Heier, M. ; Molnos, S. ; Strobl, R.* ; Schulz, H. ; Breier, M. ; Faus-Kessler, T. ; Küster, D.M. ; Wulff, A. ; Grallert, H. ; Grill, E.* ; Peters, A. ; Graw, J.

Common eye diseases in older adults of Southern Germany: Results from the KORA-Age Study.

Age Ageing 46, 481-486 (2017)
Verlagsversion Forschungsdaten DOI PMC
Creative Commons Lizenzvertrag
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Purpose a population-based study in the region of Augsburg (Germany, KORA) was used to identify the prevalence of eye diseases and their risk factors in a sample of aged individuals. Methods data originated from the KORA-Age study collected in 2012 and 822 participants (49.6% women, 50.4% men, aged 68–96 years) were asked standardised questions about eye diseases. Positive answers were validated and specified by treating ophthalmologists. Additional information came from laboratory data. Polymorphic markers were tested for candidate genes. Results we received validations and specifications for 339 participants. The most frequent eye diseases were cataracts (299 cases, 36%), dry eyes (120 cases, 15%), glaucoma (72 cases, 9%) and age-related macular degeneration (AMD) (68 cases, 8%). Almost all participants suffering from glaucoma or from AMD also had cataracts. Cataract surgery was associated with diabetes (in men; OR = 2.24; 95% confidence interval [CI] 1.11–4.53; P = 0.025) and smoking (in women; OR = 6.77; CI 1.62–28.35; P = 0.009). In men, treatments in airway diseases was associated with cataracts (glucocorticoids: OR = 5.29, CI 1.20–23.37; P = 0.028; sympathomimetics: OR = 4.57, CI 1.39–15.00; P = 0.012). Polymorphisms in two genes were associated with AMD (ARMS2: OR = 2.28, CI 1.48–3.51; P = 0.005; CFH: OR = 2.03, CI 1.35–3.06; P = 0.010). Conclusion combinations of eye diseases were frequent at old age. The importance of classical risk factors like diabetes, hypertension and airway diseases decreased either due to a survivor bias leaving healthier survivors in the older age group, or due to an increased influence of other up to now unknown risk factors.  
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter older people; population study; ageing cataract; AMD; glaucoma; Visual Impairment; Macular Degeneration; Population; Epidemiology; Risk; Prevention; Prevalence; Blindness; Cataract; Europe
Sprache
Veröffentlichungsjahr 2017
Prepublished im Jahr 2016
HGF-Berichtsjahr 2016
ISSN (print) / ISBN 0002-0729
e-ISSN 1468-2834
Zeitschrift Age and Ageing
Quellenangaben Band: 46, Heft: 3, Seiten: 481-486 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Institute of Health Economics and Health Care Management (IGM)
Institute of Developmental Genetics (IDG)
POF Topic(s) 30202 - Environmental Health
30503 - Chronic Diseases of the Lung and Allergies
30204 - Cell Programming and Repair
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-002
G-504000-006
G-504091-002
G-503900-003
G-504090-001
G-505300-002
G-500500-002
DOI 10.1093/ageing/afw234
WOS ID WOS:000400901800025
PubMed ID 27974306
Erfassungsdatum 2016-11-25
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