Non-negative constrained inversion approaches for unmixing chromophores in multispectral optoacoustic tomography.
Proc. SPIE 10064:100641B (2017)
Due to modeling and experimental imperfections, multispectral optoacoustic tomography images are often afflicted with negative values, which are further amplified when propagating into the spectrally unmixed images of chromophore concentrations. Since negative values have no physical meaning, accuracy can potentially be improved by imposing non-negativity constraints on the initial reconstructions and the unmixing steps. Herein, we compare several non-negative constrained approaches with reconstruction and spectral unmixing performed separately or combined in a single inverse step. The quantitative performance and sensitivity of the different approaches in detecting small amounts of spectrally-distinct chromophores are studied in tissue-mimicking phantoms and mouse experiments.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Typ der Hochschulschrift
Herausgeber
Schlagwörter
Optoacoustic/photoacoustic tomography, multispectral imaging, spectral unmixing, non-negative constraint
Keywords plus
Sprache
Veröffentlichungsjahr
2017
Prepublished im Jahr
HGF-Berichtsjahr
2017
ISSN (print) / ISBN
0277-786X
e-ISSN
1996-756X
ISBN
Bandtitel
Konferenztitel
Photons Plus Ultrasound: Imaging and Sensing 2017
Konferzenzdatum
28 January - 2 February 2017
Konferenzort
San Francisco, California, United States
Konferenzband
Quellenangaben
Band: 10064,
Heft: ,
Seiten: ,
Artikelnummer: 100641B
Supplement: ,
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Verlag
SPIE
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Tag d. mündl. Prüfung
0000-00-00
Betreuer
Gutachter
Prüfer
Topic
Hochschule
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Veröffentlichungsdatum
0000-00-00
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
Anmeldeland
Priorität
Begutachtungsstatus
Peer reviewed
POF Topic(s)
30205 - Bioengineering and Digital Health
Forschungsfeld(er)
Enabling and Novel Technologies
PSP-Element(e)
G-505590-001
Förderungen
Copyright
Erfassungsdatum
2017-03-20