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Rosentreter, T. ; Müller, B.* ; Schlattl, H. ; Hoeschen, C.

Experimental investigation of a HOPG crystal fan for x-ray fluorescence molecular imaging.

Proc. SPIE 10132:101325P (2017)
Postprint DOI
Open Access Green
Imaging x-ray fluorescence generally generates a conflict between the best image quality or highest sensitivity and lowest possible radiation dose. Consequently many experimental studies investigating the feasibility of this molecular imaging method, deal with either monochromatic x-ray sources that are not practical in clinical environment or accept high x-ray doses in order to maintain the advantage of high sensitivity and producing high quality images. In this work we present a x-ray fluorescence imaging setup using a HOPG crystal fan construction consisting of a Bragg reflecting analyzer array together with a scatter reducing radial collimator. This method allows for the use of polychromatic x-ray tubes that are in general easily accessible in contrast to monochromatic x-ray sources such as synchrotron facilities. Moreover this energy-selecting device minimizes the amount of Compton scattered photons while simultaneously increasing the fluorescence signal yield, thus significantly reducing the signal to noise ratio. The aim is to show the feasibility of this approach by measuring the Bragg reflected Kα fluorescence signal of an object containing an iodine solution using a large area detector with moderate energy resolution. Contemplating the anisotropic energy distribution of background scattered x-rays we compare the detection sensitivity, applying two different detector angular configurations. Our results show that even for large area detectors with limited energy resolution, iodine concentrations of 0.12 % can be detected. However, the potentially large scan times and therefore high radiation dose need to be decreased in further investigations.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter x-ray fluorescence, molecular imaging, high-Z tracers, HOPG, diffraction on crystals
Sprache englisch
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 0277-786X
e-ISSN 1996-756X
Konferenztitel Medical Imaging 2017: Physics of Medical Imaging
Konferzenzdatum 11 February 2017
Konferenzort Orlando, Florida, United States
Zeitschrift Proceedings of SPIE
Quellenangaben Band: 10132, Heft: , Seiten: , Artikelnummer: 101325P Supplement: ,
Verlag SPIE
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Protection (ISS)
Institute of Radiation Medicine (IRM)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30203 - Molecular Targets and Therapies
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-501100-008
G-501391-001
DOI 10.1117/12.2253858
Scopus ID 85020435916
Erfassungsdatum 2017-03-20
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