PuSH - Publikationsserver des Helmholtz Zentrums München: Sodium storage in human tissues is mediated by glycosaminoglycan expression.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Fischereder, M.* ; Michalke, B. ; Schmoeckel, E.* ; Habicht, A.* ; Kunisch, R.* ; Pavelic, I.* ; Szabados, B.* ; Schönermarck, U.* ; Nelson, P.* ; Stangl, M.*

Sodium storage in human tissues is mediated by glycosaminoglycan expression.

Am. J. Physiol.-Renal Physiol. 313, F319-F325 (2017)

Verlagsversion

Postprint

DOI

PMC

	Open Access Gold

Abstract
Metriken
Zusatzinfos

The current paradigm regarding sodium handling in animals and humans postulates that total body sodium is regulated predominately via regulation of extracellular volume. Active sodium storage independent of volume retention is thought to be negligible. However, studies in animals, hypertensive patients and healthy humans suggest non-osmotic storage of sodium in skin. We hypothesized that tissue sodium concentrations ([Na]T) found in humans vary and reflect regulation due to variable glycosaminoglycan content due to variable expression of XYLT-1. 27 patients on dialysis and 21 living kidney transplant donors free of clinically detectable edema were studied. During surgery, abdominal skin, muscle and arteries were biopsied. [Na]T was determined by inductively coupled plasma - optical emission spectrometry, semiquantitative glycosaminoglycan content with Alcian stain, XYLT-1 expression by real-time PCR. [Na]T of arteries were ranging between 0.86 and 9.83 g/kg wet weight and were significantly higher in arteries (4.52 ± 1.82 g/kg) than in muscle (2.03 ± 1.41 g/kg; p<0.001) or skin (3.24 ± 2.26 g/kg wet weight; p=0.038). For individual patients [Na]T correlated for skin and arterial tissue (r=0.440, p=0.012). [Na]T also correlated significantly with blinded semiquantitative analysis of glycosaminoglycans staining (r=0.588, p=0.004). In arteries XYLT-1 expression was also correlated with [Na]T (r=0.392, p=0.003). Our data confirm highly variable [Na]T in human skin and muscle and extend this observation to [Na]T in human arteries. These data support the hypothesis of water-independent sodium storage via regulated glycosaminoglycan synthesis in human tissues, including arteries.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

3.611

0.968