PuSH - Publikationsserver des Helmholtz Zentrums München: Influence of lung CT changes in chronic obstructive pulmonary disease (COPD) on the human lung microbiome.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Engel, M. ; Endesfelder, D. ; Schloter-Hai, B. ; Kublik, S. ; Granitsiotis, M.S. ; Boschetto, P.* ; Stendardo, M.* ; Barta, I.* ; Döme, B.* ; Deleuze, J.F.* ; Boland, A.* ; Müller-Quernheim, J.* ; Prasse, A.* ; Welte, T.* ; Hohlfeld, J.* ; Subramanian, D.* ; Parr, D.* ; Gut, I.G.* ; Greulich, T.* ; Koczulla, A.R.* ; Nowinski, A.* ; Gorecka, D.* ; Singh, D.* ; Gupta, S.* ; Brightling, C.E.* ; Hoffmann, H.* ; Frankenberger, M. ; Hofer, T.P. ; Burggraf, D. ; Heiss-Neumann, M.S. ; Ziegler-Heitbrock, L. ; Schloter, M. ; zu Castell, W.

Influence of lung CT changes in chronic obstructive pulmonary disease (COPD) on the human lung microbiome.

PLoS ONE 12:e0180859 (2017)

Verlagsversion

Forschungsdaten

DOI

PMC

	Open Access Gold

Abstract
Metriken
Zusatzinfos

BACKGROUND: Changes in microbial community composition in the lung of patients suffering from moderate to severe COPD have been well documented. However, knowledge about specific microbiome structures in the human lung associated with CT defined abnormalities is limited. METHODS: Bacterial community composition derived from brush samples from lungs of 16 patients suffering from different CT defined subtypes of COPD and 9 healthy subjects was analyzed using a cultivation independent barcoding approach applying 454-pyrosequencing of 16S rRNA gene fragment amplicons. RESULTS: We could show that bacterial community composition in patients with changes in CT (either airway or emphysema type changes, designated as severe subtypes) was different from community composition in lungs of patients without visible changes in CT as well as from healthy subjects (designated as mild COPD subtype and control group) (PC1, Padj = 0.002). Higher abundance of Prevotella in samples from patients with mild COPD subtype and from controls and of Streptococcus in the severe subtype cases mainly contributed to the separation of bacterial communities of subjects. No significant effects of treatment with inhaled glucocorticoids on bacterial community composition were detected within COPD cases with and without abnormalities in CT in PCoA. Co-occurrence analysis suggests the presence of networks of co-occurring bacteria. Four communities of positively correlated bacteria were revealed. The microbial communities can clearly be distinguished by their associations with the CT defined disease phenotype. CONCLUSION: Our findings indicate that CT detectable structural changes in the lung of COPD patients, which we termed severe subtypes, are associated with alterations in bacterial communities, which may induce further changes in the interaction between microbes and host cells. This might result in a changed interplay with the host immune system.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

2.806

1.092