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Kaloff, C. ; Anastassiadis, K.* ; Ayadi, A.* ; Baldock, R.* ; Beig, J. ; Birling, M.C.* ; Bradley, A.* ; Brown, S.D.M.* ; Bürger, A. ; Bushell, W.* ; Chiani, F.* ; Collins, F.S.* ; Doe, B.* ; Eppig, J.T.* ; Finnell, R.H.* ; Fletcher, C.* ; Flicek, P.* ; Fray, M.* ; Friedel, R.H.* ; Gambadoro, A.* ; Gates, H.* ; Hansen, J. ; Herault, Y.* ; Hicks, G.G.* ; Hörlein, A. ; Hrabě de Angelis, M. ; Iyer, V.* ; de Jong, P.J.* ; Koscielny, G.* ; Kühn, R. ; Liu, P.* ; Lloyd, K.C.K.* ; Lopez, R.G.* ; Marschall, S. ; Martínez, S.* ; McKerlie, C.* ; Meehan, T.F.* ; von Melchner, H.* ; Moore, M.* ; Murray, S.A.* ; Nagy, A.* ; Nutter, L.M.J.* ; Pavlovic, G.* ; Pombero, A.* ; Prosser, H.* ; Ramirez-Solis, R.* ; Ringwald, M.* ; Rosen, B.* ; Rosenthal, N.* ; Rossant, J.* ; Ruiz Noppinger, P.* ; Ryder, E.* ; Skarnes, W.C.* ; Schick, J. ; Schnütgen, F.* ; Schofield, P.* ; Seisenberger, C. ; Selloum, M.* ; Smedley, D.* ; Simpson, E.M.* ; Stewart, A.F.* ; Teboul, L.* ; Tocchini Valentini, G.P.* ; Valenzuela, D.* ; West, A.P.* ; Wurst, W.

Genome wide conditional mouse knockout resources.

Drug Discov. Today, DOI: 10.1016/j.ddmod.2017.08.002 (2017)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
© 2017 Elsevier Ltd. The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which have been archived and are freely available to the research community as a frozen resource. From this unprecedented resource more than 6000 mutant mouse strains have been generated by the IKMC in collaboration with the International Mouse Phenotyping Consortium (IMPC). In addition, a cre-driver resource was established including 250 C57BL/6 cre-inducible mouse strains. Complementing the cre-driver resource, a collection comprising 27 rAAVs expressing cre in a tissue-specific manner has also been produced. All resources are easily accessible from the IKMC/IMPC web portal (www.mousephenotype.org). The IKMC/IMPC resource is a standardized reference library of mouse models with defined genetic backgrounds enabling the analysis of gene-disease associations in mice of different genetic makeup and should therefore have a major impact on biomedical research.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 1359-6446
e-ISSN 1878-5832
Zeitschrift Drug discovery today
Verlag Elsevier
Verlagsort Cambridge
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)
Institute of Experimental Genetics (IEG)
Institute of Molecular Toxicology and Pharmacology (TOX)
POF Topic(s) 30204 - Cell Programming and Repair
30201 - Metabolic Health
30203 - Molecular Targets and Therapies
Forschungsfeld(er) Genetics and Epidemiology
Enabling and Novel Technologies
PSP-Element(e) G-500500-001
G-500600-001
G-500692-001
G-505200-001
DOI 10.1016/j.ddmod.2017.08.002
Scopus ID 85029227398
Erfassungsdatum 2017-09-28
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