PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Mitroulis, I.* ; Ruppova, K.* ; Wang, B.* ; Chen, L.S.* ; Grzybek, M. ; Grinenko, T.* ; Eugster, A.* ; Troullinaki, M.* ; Palladini, A. ; Kourtzelis, I.* ; Chatzigeorgiou, A.* ; Schlitzer, A.* ; Beyer, M.* ; Joosten, L.A.B.* ; Isermann, B.* ; Lesche, M.* ; Petzold, A.* ; Simons, K.* ; Henry, I.* ; Dahl, A.* ; Schultze, J.L.* ; Wielockx, B.* ; Zamboni, N.* ; Mirtschink, P.* ; Coskun, Ü. ; Hajishengallis, G.* ; Netea, M.G.* ; Chavakis, T.*

Modulation of myelopoiesis progenitors is an integral component of trained immunity.

Cell 172, 147-161.e12 (2018)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Trained innate immunity fosters a sustained favorable response of myeloid cells to a secondary challenge, despite their short lifespan in circulation. We thus hypothesized that trained immunity acts via modulation of hematopoietic stem and progenitor cells (HSPCs). Administration of beta-glucan (prototypical trained-immunity-inducing agonist) to mice induced expansion of progenitors of the myeloid lineage, which was associated with elevated signaling by innate immune mediators, such as IL-1 beta and granulocyte-macrophage colony-stimulating factor (GM-CSF), and with adaptations in glucose metabolism and cholesterol biosynthesis. The trained-immunity-related increase in myelopoiesis resulted in a beneficial response to secondary LPS challenge and protection from chemotherapy-induced myelosuppression in mice. Therefore, modulation of myeloid progenitors in the bone marrow is an integral component of trained immunity, which to date, was considered to involve functional changes of mature myeloid cells in the periphery.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
31.398
5.008
387
383
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Gm-csf ; Cholesterol Biosynthesis ; Glycolysis ; Inflammation ; Innate Immune Memory ; Interleukin-1β ; Myelopoiesis ; Myelosuppression ; Trained Innate Immunity ; β-glucan; Hematopoietic Stem-cells; High-throughput; Self-renewal; Mass-spectrometry; Lineage Commitment; Global Analysis; Hypoxic Niche; Proliferation; Dormancy; Mice
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 0092-8674
e-ISSN 1097-4172
Zeitschrift Cell
Quellenangaben Band: 172, Heft: 1-2, Seiten: 147-161.e12 Artikelnummer: , Supplement: ,
Verlag Cell Press
Verlagsort Cambridge, Mass.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502600-002
G-502600-008
DOI 10.1016/j.cell.2017.11.034
WOS ID WOS:000419840100016
Scopus ID 85041099114
PubMed ID 29328910
Erfassungsdatum 2018-02-28
[➜Korrektur melden]