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Haag, S.* ; Friedrich, B.* ; Peter, A. ; Häring, H.-U. ; Heyne, N. ; Artunc, F.

Systemic haemodynamics in haemodialysis: Intradialytic changes and prognostic significance.

Nephrol. Dial. Transplant. 33, 1419-1427 (2018)
Verlagsversion Forschungsdaten DOI PMC
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Background. Although haemodialysis (HD) leads to alterations of systemic haemodynamics that can be monitored using dilution methods, there is a lack of data on the diagnostic and prognostic significance of haemodynamic monitoring during routine HD. Methods. In this multicentre study, we measured cardiac index (CI), access flow (AF) and central blood volume index (CBVI) during a single HD session in stable HD patients (n ¼ 215) using the Transonic HD03 monitor (Transonic, Ithaca, NY, USA). Systemic CI (SCI) was defined as CI corrected for AF. In a subset of patients (n ¼ 82), total end-diastolic volume index (TEDVI) and total ejection fraction (TEF) were derived from dilution curves. Data were correlated with clinical parameters, cardiac biomarkers and bioimpedance measurements (body composition monitor; Fresenius Medical Care, Homburg, Germany). Mortality was assessed prospectively after a median follow-up of 2.6 years. Results. Median CI, CBVI and AF were 2.8 L/min/m2 (interquartile range 2.4–3.4), 15 mL/kg (14.5–15.7) and 980 mL/min (740–1415), respectively, at the beginning of HD. At the end of HD, CI, CBVI and AF significantly fell by 10% (22 to 3, P < 0.0001), 9% (23 to 3, P < 0.0001) and 4% (13 to 5, P ¼ 0.0004), respectively. Peripheral resistance (PR) increased slightly (P ¼ 0.01) and blood pressure fell by 6/3 mmHg to 128/63 mmHg (P < 0.0001). Independent predictors of DCI were age and ultrafiltration rate, whereas AF, overhydration and PR were protective. TEF was strongly associated with mortality [area under the dilution curve 0.77, P < 0.0001], followed by TEDVI (0.72, P ¼ 0.0002) and SCI (0.60, P ¼ 0.02). Conclusions. HD leads to a reduction of CI due to ultrafiltration. Haemodynamic monitoring identifies a significant number of HD patients with cardiac impairment that are at risk for increased mortality.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cardiac Index ; Haemodialysis ; Haemodynamics ; Prognosis ; Ultrasound Dilution; Ventricular Ejection Fraction; Access Flow Measurement; Measure Cardiac-output; Blood-volume; Cardiovascular-disease; Ultrasound Dilution; Dialysis Patients; Renal-disease; Mortality; Validation
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 0931-0509
e-ISSN 1460-2385
Zeitschrift Nephrology Dialysis Transplantation
Quellenangaben Band: 33, Heft: 8, Seiten: 1419-1427 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Great Clarendon St, Oxford Ox2 6dp, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
G-502400-002
DOI 10.1093/ndt/gfy041
WOS ID WOS:000440947400020
Scopus ID 85055203441
PubMed ID 29590459
Erfassungsdatum 2018-09-07
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