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Martinez Jimenez, C.P. ; Sandoval, J.*

Epigenetic crosstalk: a molecular language in human metabolic disorders.

Front. Biosci. 7, 46-57 (2015)
Postprint PMC
Open Access Green
Technological breakthroughs are emphasizing the impact of epigenetic mechanisms in human health highlighting the importance of a fine-tune orchestration of DNA methylation, micro RNAs, histone modifications, and chromatin structure. Transcriptional regulators sense the concentration of intermediary metabolites associated to a wide variety of biological processes including the long-term imprinting and heritable DNA methylation. Recent epigenetic mechanisms associated with cholesterol and lipid homeostasis have a critical impact in the susceptibility, development and progression of complex diseases such as type 2 diabetes mellitus, non-alcoholic fatty liver, obesity and metabolic syndrome. The heritability of epigenetic states emerge as an additional level of complexity where the extension of somatic as well as inherited epigenetic modifications may require a thoughtful reconsideration in many human diseases related with metabolic disorders.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 1093-9946
e-ISSN 1093-4715
Zeitschrift Frontiers in Bioscience
Quellenangaben Band: 7, Heft: , Seiten: 46-57 Artikelnummer: , Supplement: ,
Verlag Frontiers
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Pioneer Campus (HPC)
PubMed ID 25961686
Erfassungsdatum 2019-01-17
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