PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Ma, J.* ; Nano, J. ; Ding, J.* ; Zheng, Y.* ; Hennein, R.* ; Liu, C.* ; Speliotes, E.K.* ; Huan, T.* ; Song, C.* ; Mendelson, M.M.* ; Joehanes, R.* ; Long, M.T.* ; Liang, L.* ; Smith, J.A.* ; Reynolds, L.M.* ; Ghanbari, M.* ; Muka, T.* ; van Meurs, J.B.J.* ; Alferink, L.J.M.* ; Franco, O.H.* ; Dehghan, A.* ; Ratliff, S.* ; Zhao, W.* ; Bielak, L.F.* ; Kardia, S.L.R.* ; Peyser, P.A.* ; Ning, H.* ; VanWagner, L.B.* ; Lloyd-Jones, D.M.* ; Carr, J.J.* ; Greenland, P.* ; Lichtenstein, A.H.* ; Hu, F.B.* ; Liu, Y.* ; Hou, L.* ; Darwish Murad, S.* ; Levy, D.*

A peripheral blood DNA methylation signature of hepatic fat reveals a potential causal pathway for non-alcoholic fatty liver disease.

Diabetes 68, 1073-1083 (2019)
Verlagsversion Postprint Forschungsdaten DOI PMC
Open Access Green
Nonalcoholic fatty liver disease (NAFLD) is a risk factor for type 2 diabetes (T2D). We aimed to identify the peripheral blood DNA methylation signature of hepatic fat. We conducted epigenome-wide association studies of hepatic fat in 3,400 European ancestry (EA) participants and in 401 Hispanic ancestry and 724 African ancestry participants from four population-based cohort studies. Hepatic fat was measured using computed tomography or ultrasound imaging and DNA methylation was assessed at >400,000 cytosine-guanine dinucleotides (CpGs) in whole blood or CD14+ monocytes using a commercial array. We identified 22 CpGs associated with hepatic fat in EA participants at a false discovery rate <0.05 (corresponding P = 6.9 x 10(-6)) with replication at Bonferroni-corrected P < 8.6 x 10(-4). Mendelian randomization analyses supported the association of hypomethylation of cg08309687 (LINC00649) with NAFLD (P = 2.5 x 10(-4)). Hypomethylation of the same CpG was also associated with risk for new-onset T2D (P = 0.005). Our study demonstrates that a peripheral blood-derived DNA methylation signature is robustly associated with hepatic fat accumulation. The hepatic fat-associated CpGs may represent attractive biomarkers for T2D. Future studies are warranted to explore mechanisms and to examine DNA methylation signatures of NAFLD across racial/ethnic groups.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
7.199
1.796
15
18
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Epigenome-wide Association; Cardiovascular-disease; Diabetes-mellitus; Steatohepatitis
Sprache englisch
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Zeitschrift Diabetes
Quellenangaben Band: 68, Heft: 5, Seiten: 1073-1083 Artikelnummer: , Supplement: ,
Verlag American Diabetes Association
Verlagsort Alexandria, VA.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-002
DOI 10.2337/DB18-1193
WOS ID WOS:000466756900022
Scopus ID 85065112934
PubMed ID 30936141
Erfassungsdatum 2019-05-10
[➜Korrektur melden]