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Wang, X. ; Malinowski, A.R. ; Beckenbauer, J. ; Siehler, J. ; Blöchinger, A. ; Meitinger, T. ; Häring, H.-U. ; Staiger, H. ; Burtscher, I. ; Lickert, H.

Generation of a human induced pluripotent stem cell line (HMGUi002-A) from a healthy male individual.

Stem Cell Res. 39:101531 (2019)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Induced pluripotent stem cells (iPSCs) can be used to generate different somatic cell types in vitro, including insulin-producing pancreatic beta-cells. Here, we have generated iPSCs from a healthy male individual using an episomal reprogramming method. The resulting iPSCs are integration-free, have a normal karyotype and are pluripotent in vitro and in vivo. Furthermore, we show that this iPSC line can be differentiated into pancreatic lineage cells. Taken together, this iPSC line will be useful to test differentiation protocols towards beta-cell as well as other cell types and will also serve as a control for drug development and disease modelling studies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 1873-5061
e-ISSN 1876-7753
Zeitschrift Stem Cell Research
Quellenangaben Band: 39, Heft: , Seiten: , Artikelnummer: 101531 Supplement: ,
Verlag Elsevier
Verlagsort Radarweg 29, 1043 Nx Amsterdam, Netherlands
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Regeneration Research (IDR)
Institute of Human Genetics (IHG)
Institute of Diabetes Research and Metabolic Diseases (IDM)
POF Topic(s) 30201 - Metabolic Health
90000 - German Center for Diabetes Research
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Helmholtz Diabetes Center
Genetics and Epidemiology
PSP-Element(e) G-502300-001
G-501900-231
G-500700-001
G-502400-001
DOI 10.1016/j.scr.2019.101531
WOS ID WOS:000487828400040
Scopus ID 85070517938
PubMed ID 31419739
Erfassungsdatum 2019-09-27
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