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Abukhalil, M.H.* ; Hussein, O.E.* ; Bin-Jumah, M.* ; Saghir, S.A.M.* ; Germoush, M.O.* ; Elgebaly, H.A.* ; Mosa, N.M.* ; Hamad, I.* ; Qarmush, M.M.* ; Hassanein, E.M.* ; Kamel, E.M.* ; Hernandez-Bautista, R. ; Mahmoud, A.M.*

Farnesol attenuates oxidative stress and liver injury and modulates fatty acid synthase and acetyl-CoA carboxylase in high cholesterol-fed rats.

Environ. Sci. Pollut. Res. 27, 30118-30132 (2020)
Postprint DOI
Open Access Green
Dyslipidemia is a risk factor for cardiovascular disease, steatohepatitis, and progression of liver disorders. This study investigated the protective effect of farnesol (FAR), a sesquiterpene alcohol, against liver injury in high cholesterol diet (HCD)-fed rats, and its modulatory effect on fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC). HCD was supplemented for 10 weeks, and the rats were concurrently treated with FAR. Rats that received HCD exhibited significant elevation of serum cholesterol, triacylglycerols, LDL and vLDL cholesterol, CRP, and pro-inflammatory cytokines and increased values of the cardiovascular risk indices. Serum transaminases, ALP, LDH and CK-MB, and hepatic lipid peroxidation (LPO), cholesterol, and triacylglycerols were increased in HCD-fed rats. Treatment with FAR greatly ameliorated dyslipidemia and liver function, reduced inflammatory mediators, LPO, and hepatic lipid infiltration and enhanced anti-oxidant defenses. FAR suppressed hepatic FAS, ACC, and SREPB-1c mRNA abundance and FAS activity in HDC-fed rats. In addition, molecular docking simulations pinpointed the binding modes of FAR to the active pocket residues of FAS and ACC. In conclusion, FAR possesses a strong anti-hyperlipidemic/anti-hypercholesterolemic activity mediated through its ability to modulate hepatic FAS, ACC, and SREPB-1c. FAR prevented oxidative stress, inflammation, and liver injury induced by HCD. Thus, FAR may represent a promising lipid-lowering agent that can protect against dyslipidemia and its linked metabolic deregulations.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Sesquiterpenes ; Hypercholesterolemia ; Farnesol ; Molecular Docking ; Oxidative Stress ; Steatosis; Lipid-accumulation; Adipose-tissue; Hypercholesterolemia; Disease; Mice; Dysregulation; Proliferation; Biosynthesis; Dysfunction; Simvastatin
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 0944-1344
e-ISSN 1614-7499
Zeitschrift Environmental Science and Pollution Research
Quellenangaben Band: 27, Heft: 24, Seiten: 30118-30132 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Tiergartenstrasse 17, D-69121 Heidelberg, Germany
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502200-001
DOI 10.1007/s11356-020-09296-w
WOS ID WOS:000535165700002
Scopus ID 85085310838
Erfassungsdatum 2020-06-05
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