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Kruse, M.* ; Kemper, M.* ; Gancheva, S.* ; Osterhoff, M.* ; Dannenberger, D.* ; Markgraf, D.* ; Machann, J. ; Hierholzer, J.* ; Roden, M.* ; Pfeiffer, A.F.H.*

Dietary rapeseed oil supplementation reduces hepatic steatosis in obese men-a randomized controlled trial.

Mol. Nutr. Food Res. 64:e2000419 (2020)
Postprint Forschungsdaten DOI PMC
Open Access Green
Scope Effective treatment for obesity associated non-alcoholic fatty liver disease (NAFLD) is limited. Dietary supplementation of n-3 polyunsaturated fatty acids, specifically alpha linolenic acid (ALA), can resolve intrahepatic lipid content (IHL). This study investigates the effect of daily supplementation of either refined rapeseed (RA), containing high amounts of ALA, or refined olive (OL) oil on IHL and glucose metabolism in NAFLD patients. Methods and results 27 obese men consumed an isocaloric diet including either 50 g of RA or OL daily for 8 weeks. Hepatic proton magnetic resonance spectroscopy, hyperinsulinemic-euglycemic clamp studies and blood tests are performed before and at the end of the study. At 8 weeks a significant reduction in IHL is observed for RA (13.1 +/- 1.6 before versus 11.1 +/- 1.6% after intervention) versus OL (13.3 +/- 2.5 before versus 15.7 +/- 2.7% after intervention). For RA, a 21% reduction (P< 0.02) in serum free fatty acids (FFA) and a 1.68-fold increase (P= 0.03) of serum interleukin-6 (IL-6) is observed after 8 weeks. Conclusion RA has a beneficial effect on hepatic lipid metabolism as shown by reduced IHL and serum FFA. RA induced IL-6 production seems to be liver protective confirming previous results.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Hepatic Steatosis ; Obesity ; Olive Oil ; Rapeseed Oil ; Serum Lipids; Nonalcoholic Fatty Liver; Alpha-linolenic Acid; Insulin-resistance; Adipose-tissue; Metabolic Syndrome; N-6/n-3 Ratio; Disease; Inflammation; Glucose; Risk
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 1613-4125
e-ISSN 1613-4133
Zeitschrift Molecular Nutrition and Food Research
Quellenangaben Band: 64, Heft: 21, Seiten: , Artikelnummer: e2000419 Supplement: ,
Verlag Wiley
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
Förderungen German Federal Ministry of Education and Research
Union zur Forderung von Oel- und Proteinpflanzen e. V., Germany
DOI 10.1002/mnfr.202000419
WOS ID WOS:000575456600001
Scopus ID 85092089808
PubMed ID 32920973
Erfassungsdatum 2020-10-30
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