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Karabegović, I.* ; Portilla-Fernandez, E.* ; Li, Y.* ; Ma, J.* ; Maas, S.C.E.* ; Sun, D.* ; Hu, E.A.* ; Kühnel, B. ; Zhang, Y.* ; Ambatipudi, S.* ; Fiorito, G.* ; Huang, J.* ; Castillo-Fernandez, J.E.* ; Wiggins, K.L.* ; de Klein, N.* ; Grioni, S.* ; Swenson, B.R.* ; Polidoro, S.* ; Treur, J.L.* ; Cuenin, C.* ; Tsai, P.C.* ; Costeira, R.* ; Chajes, V.* ; Braun, K.* ; Verweij, N.* ; Kretschmer, A. ; Franke, L.* ; van Meurs, J.B.J.* ; Uitterlinden, A.G.* ; de Knegt, R.J.* ; Ikram, M.A.* ; Dehghan, A.* ; Peters, A. ; Schöttker, B.* ; Gharib, S.A.* ; Sotoodehnia, N.* ; Bell, J.T.* ; Elliott, P.* ; Vineis, P.* ; Relton, C.* ; Herceg, Z.* ; Brenner, H.* ; Waldenberger, M. ; Rebholz, C.M.* ; Voortman, T.* ; Pan, Q.* ; Fornage, M.* ; Levy, D.* ; Kayser, M.* ; Ghanbari, M.*

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption.

Nat. Commun. 12:2830 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is consistently linked to, among others, reduced risk of diabetes and liver diseases; however, the mechanisms of action remain elusive. Epigenetics is suggested as a mechanism mediating the effects of dietary and lifestyle factors on disease onset. Here we report the results from epigenome-wide association studies (EWAS) on coffee and tea consumption in 15,789 participants of European and African-American ancestries from 15 cohorts. EWAS meta-analysis of coffee consumption reveals 11 CpGs surpassing the epigenome-wide significance threshold (P-value <1.1×10-7), which annotated to the AHRR, F2RL3, FLJ43663, HDAC4, GFI1 and PHGDH genes. Among them, cg14476101 is significantly associated with expression of the PHGDH and risk of fatty liver disease. Knockdown of PHGDH expression in liver cells shows a correlation with expression levels of genes associated with circulating lipids, suggesting a role of PHGDH in hepatic-lipid metabolism. EWAS meta-analysis on tea consumption reveals no significant association, only two CpGs annotated to CACNA1A and PRDM16 genes show suggestive association (P-value <5.0×10-6). These findings indicate that coffee-associated changes in DNA methylation levels may explain the mechanism of action of coffee consumption in conferring risk of diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Polycyclic Aromatic-hydrocarbons; Activated Receptor 4; Mendelian Randomization; Epigenetics; Risk; Population; Caffeine; Disease; Design; Cancer
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 12, Heft: 1, Seiten: , Artikelnummer: 2830 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504091-001
G-504000-010
Förderungen Wellcome Trust
NCATS NIH HHS
Medical Research Council
Department of Health
NINDS NIH HHS
NIA NIH HHS
NHLBI NIH HHS
Biotechnology and Biological Sciences Research Council
DOI 10.1038/s41467-021-22752-6
WOS ID WOS:000658732600005
Scopus ID 85105965013
PubMed ID 33990564
Erfassungsdatum 2021-06-21
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