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Briukhovetska, D.* ; Dörr, J.* ; Endres, S. ; Libby, P.* ; Dinarello, C.A.* ; Kobold, S.

Interleukins in cancer: From biology to therapy.

Nat. Rev. Cancer 21, 481–499 (2021)
Verlagsversion Postprint DOI PMC
Open Access Green
Interleukins and associated cytokines serve as the means of communication for innate and adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a critical role in cancer development, progression and control. Interleukins can nurture an environment enabling and favouring cancer growth while simultaneously being essential for a productive tumour-directed immune response. These properties of interleukins can be exploited to improve immunotherapies to promote effectiveness as well as to limit side effects. This Review aims to unravel some of these complex interactions.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Cd4(+) T-cells; Phase-i Trial; Anti-interleukin-6 Monoclonal-antibody; Reduced Clinical Benefit; Natural-killer-cells; Colorectal-cancer; Multiple-myeloma; Siltuximab Anti-il-6; Il-15 Superagonist; Immune Activation
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 1474-175X
e-ISSN 1474-1768
Zeitschrift Nature Reviews - Cancer
Quellenangaben Band: 21, Heft: , Seiten: 481–499 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort Heidelberger Platz 3, Berlin, 14197, Germany
Begutachtungsstatus Peer reviewed
Institut(e) Unit for Clinical Pharmacology (KKG-EKLiP)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-522100-001
Förderungen Jose Carreras Foundation
Hector foundation
Melanoma Research Alliance grant
Else Kroner-Fresenius-Stiftung
German Cancer Aid
international doctoral programme i Target: Immunotargeting of Cancer - Elite Network of Bavaria
Ernst-Jung-Stiftung
LMU Munich's institutional strategy LMU excellent within German Excellence Initiative
Bundesministerium fur Bildung und Forschung Project Oncoattract
European Research Council grant
German Research Foundation
Fritz Bender Foundation
Bavarian Ministry of Economical Affairs
Marie Skodowska-Curie Programme Training Network for the Immunotherapy of Cancer and Training Network for Optimizing Adoptive T Cell Therapy of Cancer - Horizon 2020 programme of the European Union
DOI 10.1038/s41568-021-00363-z
WOS ID WOS:000657554400001
Scopus ID 85107307752
PubMed ID 34083781
Erfassungsdatum 2021-07-06
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