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Oomen, M.E. ; Torres-Padilla, M.E.

Jump-starting life: balancing transposable element co-option and genome integrity in the developing mammalian embryo.

EMBO Rep. 25, 1721-1733 (2024)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Remnants of transposable elements (TEs) are widely expressed throughout mammalian embryo development. Originally infesting our genomes as selfish elements and acting as a source of genome instability, several of these elements have been co-opted as part of a complex system of genome regulation. Many TEs have lost transposition ability and their transcriptional potential has been tampered as a result of interactions with the host throughout evolutionary time. It has been proposed that TEs have been ultimately repurposed to function as gene regulatory hubs scattered throughout our genomes. In the early embryo in particular, TEs find a perfect environment of naïve chromatin to escape transcriptional repression by the host. As a consequence, it is thought that hosts found ways to co-opt TE sequences to regulate large-scale changes in chromatin and transcription state of their genomes. In this review, we discuss several examples of TEs expressed during embryo development, their potential for co-option in genome regulation and the evolutionary pressures on TEs and on our genomes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Genome Evolution ; Genome Regulation ; Preimplantation Development ; Transposable Elements; Stem-cells; Small Rnas; Endogenous Retroviruses; Dna Methylation; Mouse Embryos; Muerv-l; Evolution; Chromatin; Retrotransposons; Transcription
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 1469-221X
e-ISSN 1469-3178
Zeitschrift EMBO Reports
Quellenangaben Band: 25, Heft: 4, Seiten: 1721-1733 Artikelnummer: , Supplement: ,
Verlag EMBO Press
Verlagsort Campus, 4 Crinan St, London, N1 9xw, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epigenetics and Stem Cells (IES)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-506200-001
Förderungen EMBO
NIH 4DN program
DFG
Helmholtz Association
Helmholtz Association ((sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic))
DOI 10.1038/s44319-024-00118-5
WOS ID 001207588700025
Scopus ID 85188552573
PubMed ID 38528171
Erfassungsdatum 2024-05-23
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