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Singh, A. ; Bocher, O. ; Zeggini, E.

Insights into the molecular underpinning of type 2 diabetes complications.

Hum. Mol. Genet. 34, 469-480 (2025)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Type 2 diabetes (T2D) complications pose a significant global health challenge. Omics technologies have been employed to investigate these complications and identify the biological pathways involved. In this review, we focus on four major T2D complications: diabetic kidney disease, diabetic retinopathy, diabetic neuropathy, and cardiovascular complications. We discuss advancements in omics research, summarizing findings from genetic, epigenomic, transcriptomic, proteomic, and metabolomic studies across different ancestries and disease-relevant tissues. We stress the importance of integrating multi-omics techniques to elucidate the biological mechanisms underlying T2D complications and advocate for ancestrally diverse studies. Ultimately, these insights will improve risk prediction for T2D complications and inform translation strategies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Type 2 Diabetes Complications ; Epigenomics ; Metabolomics ; Proteomics ; Transcriptomics; Genome-wide Association; Coronary-heart-disease; Glomerular-filtration-rate; All-cause Mortality; Renal-disease; Cardiovascular-disease; Oxidative Stress; Glycemic Control; Acid-metabolism; Genetic Variant
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 0964-6906
e-ISSN 1460-2083
Zeitschrift Human Molecular Genetics
Quellenangaben Band: 34, Heft: 6, Seiten: 469-480 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Great Clarendon St, Oxford Ox2 6dp, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Translational Genomics (ITG)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-506700-001
Förderungen European Union
DOI 10.1093/hmg/ddae203
WOS ID 001395594800001
Scopus ID 105000666910
PubMed ID 39807636
Erfassungsdatum 2025-03-20
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