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Winheim, E.* ; Santos-Peral, A.* ; Ehm, T.* ; Rinke, L.* ; Riemer, S.* ; Zaucha, M. ; Goresch, S.* ; Lehmann, L.* ; Eisenächer, K.* ; Pritsch, M.* ; Barba-Spaeth, G.* ; Straub, T.* ; Rothenfußer, S. ; Krug, A.B.*

Interferon-induced activation of dendritic cells and monocytes by yellow fever vaccination correlates with early antibody responses.

Proc. Natl. Acad. Sci. U.S.A. 122:e2422236122 (2025)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Yellow fever vaccination provides long-lasting protection and is a unique model for studying the immune response to an acute RNA virus infection in humans. To elucidate the early innate immune events preceding the rapid generation of protective immunity, we performed transcriptome analysis of human blood dendritic cell (DC) and monocyte subpopulations before and 3, 7, 14, and 28 d after vaccination. We detected temporary upregulation of IFN-stimulated genes (ISG) in all DC and monocyte subsets on days 3 and 7 after vaccination as well as cell type-specific responses and response kinetics. Single-cell RNA sequencing revealed rapid appearance of activated DC and monocyte clusters dominated by ISGs, inflammatory chemokines, and genes involved in antigen processing and presentation. This was confirmed by flow cytometric analysis in a large cohort of vaccinees. We identified SIGLEC1/CD169 upregulation as a sensitive indicator of the transient IFN-induced activation state elicited in DCs and monocytes by YF17D vaccination correlating with early protective IgM antibody responses.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Dendritic Cells ; Interferon ; Monocytes ; Vaccination ; Yellow Fever Virus; Zika Virus-infection; I Interferon; Differentiation; Immunogenicity; Replication; Immunity; Pathways; Subset
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 0027-8424
e-ISSN 1091-6490
Zeitschrift Proceedings of the National Academy of Sciences of the United States of America
Quellenangaben Band: 122, Heft: 19, Seiten: , Artikelnummer: e2422236122 Supplement: ,
Verlag National Academy of Sciences
Verlagsort 2101 Constitution Ave Nw, Washington, Dc 20418 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Unit for Clinical Pharmacology (KKG-EKLiP)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-522100-001
Förderungen Agence Nationale de la Recherche (ANR)
French National Research Agency (ANR)
European Union's Horizon Europe research and innovation programme
IMed consortium of the German Helmholtz Societies
Einheit fur Klinische Pharmakologie, Helmholtz Zentrum Munchen, Neuherberg, Germany
Friedrich-Baur-Stiftung
Villigst Foundation

Deutsche Forschungsgemeinschaft (DFG) Project
DOI 10.1073/pnas.2422236122
WOS ID 001491965400001
Scopus ID 105004783886
PubMed ID 40333758
Erfassungsdatum 2025-05-11
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