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Delaval, M.N. ; Czech, H. ; Almasaleekh, M. ; Offer, S. ; Pantzke, J. ; Ihalainen, M.* ; Yli-Pirilä, P.* ; Somero, M.* ; Kortelainen, M.* ; Gawlitta, N. ; Orasche, J. ; Jakobi, G. ; Shukla, D. ; Martens, P.* ; Paul, A.* ; Fang, Z.* ; Pardo, M.* ; Barth, A.* ; Utinger, B.* ; Jeong, S. ; Rastak, N. ; Kuhn, E. ; Huber, A. ; Mukherjee, A.* ; Mesceriakovas, A.* ; Joutsensaari, J.* ; Leskinen, J.* ; Hartikainen, A.* ; Passig, J.* ; Oeder, S. ; Schnelle-Kreis, J. ; Hohaus, T.* ; Kiendler-Scharr, A.* ; Kalberer, M.* ; Di Bucchianico, S. ; Rudich, Y.* ; Sippula, O.* ; Zimmermann, R.

The efficiency of EURO 6d car particulate filters is compromised by atmospheric aging: In vitro toxicity of gasoline car exhaust.

Sci. Adv. 11:eadq2348 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Tailpipe emissions from road traffic contribute substantially to the burden of fine inhalable particulate matter (PM2.5) and deteriorate air quality. Exhaust emission standards, forcing improvements in combustion and exhaust after-treatment technology, considerably decreases combustion-related PM2.5 emitted by modern cars. A549 cancerous alveolar and BEAS-2B normal bronchial epithelial cells were exposed at the air-liquid interface to the total aerosol or gas phase of either fresh or photochemically aged tailpipe emissions from a gasoline EURO 6d car equipped with a gasoline particulate filter. Diluted fresh emissions contained particle number concentrations comparable to low ambient air levels and induced no detectable cytotoxicity. Photochemical aging led to the formation of secondary aerosols and caused significant cytotoxicity. While the aged aerosol induced significant DNA damage, oxidative stress was more associated with volatile secondary species. Our results call for the consideration of the exhaust emission atmospheric transformation processes in future emission standards toward health effect-driven emission regulations.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Oxidation Flow Reactors; Organic Aerosol Formation; Residential Wood Combustion; Ambient Air-pollution; Oxygen Species Ros; Radical Chemistry; Mass-spectrometry; Exposure; Emissions; Health
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 2375-2548
e-ISSN 2375-2548
Zeitschrift Science Advances
Quellenangaben Band: 11, Heft: 22, Seiten: , Artikelnummer: eadq2348 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort Washington, DC [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Cooperation Group Comprehensive Molecular Analytics (CMA)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Environmental Sciences
PSP-Element(e) G-504500-001
Förderungen EU Horizon
Research Council of Finland competitive funding to strengthen university research profiles (PROFI) for the University of Eastern Finland
University of Eastern Finland
EDUFI Fellowship Grant from the Finnish National Agency for Education
Research Council of Finland project BBrCAC
H2020 EU project ULtrafine particles from TRansportation-Health Assessment of Source
Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health-Aerosols and Health (HICE)
Helmholtz International Laboratory aro HEALTH
DOI 10.1126/sciadv.adq2348
WOS ID 001497915100012
Scopus ID 105007125362
PubMed ID 40435258
Erfassungsdatum 2025-06-02
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