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Miller, Z.* ; Twardowski, L.M.* ; Reader, B.F.* ; Rojas, M.* ; Lehmann, M. ; Mora, A.L.*

Mechanisms and markers of lung ageing in health and disease.

Eur. Respir. Rev. 34:240233 (2025)
Verlagsversion DOI PMC
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Creative Commons Lizenzvertrag
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Ageing significantly impacts lung function and increases susceptibility to chronic lung diseases. The lung is a complex organ with multiple cell types that undergo cellular age-related perturbations or hallmarks. As knowledge of ageing mechanisms has progressed, we have a better understanding how intracellular adaptations impact cellular crosstalk and integrate to increase the susceptibility to age-related diseases in the lung. Herein, we discuss the prospects of exhaustion of lung progenitor cells, disrupted lung cell plasticity, perturbation in fibroblasts, impaired adaptive immune responses and alterations in lung microenvironment in the promotion of ageing and age-related lung diseases. Additionally, the ageing process trajectory of the lung depends on a combination of biological, genetic, metabolic, biomechanical and sociobehavioural factors that range from protective phenotypes to accelerated ageing phenotypes. We propose the concept of AgEnOmics, which expands the temporal dimension of lung ageing by distinguishing between chronological ageing and accelerated lung ageing phenotypes. Based on this concept, we define biomarkers of biological ageing that will help to define accelerated ageing and early interventions in biological ageing-related lung diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Obstructive Pulmonary-disease; Endoplasmic-reticulum Stress; Bronchoalveolar Lavage Fluid; Epithelial-cell Senescence; Growth-factor-i; Endothelial Progenitor Cells; C-reactive Protein; Cigarette-smoke; Dna Methylation; Alveolar Macrophages
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 0905-9180
e-ISSN 1600-0617
Zeitschrift European Respiratory Review
Quellenangaben Band: 34, Heft: 177, Seiten: , Artikelnummer: 240233 Supplement: ,
Verlag European Respiratory Society
Verlagsort 442 Glossop Rd, Sheffield S10 2px, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Lung Research
PSP-Element(e) G-501600-005
Förderungen Office of the NIH
NIH Common Fund, through the Office of Strategic Coordination
NHLBI/NIH
Von Behring Rontgen Foundation
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
German Center for Lung Research (DZL)
DOI 10.1183/16000617.0233-2024
WOS ID 001541950500003
Scopus ID 105012317585
PubMed ID 40701639
Erfassungsdatum 2025-07-25
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