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Bamberg, F.* ; Hetterich, H.* ; Rospleszcz, S. ; Lorbeer, R.* ; Auweter, S.D.* ; Schlett, C.L.* ; Schafnitzel, A.* ; Bayerl, C.* ; Schindler, A.* ; Saam, T.* ; Müller-Peltzer, K.* ; Sommer, W.* ; Zitzelsberger, T.* ; Machann, J.* ; Ingrisch, M.* ; Selder, S.* ; Rathmann, W.* ; Heier, M. ; Linkohr, B. ; Meisinger, C. ; Weber, C.* ; Ertl-Wagner, B.* ; Massberg, S.* ; Reiser, M.F.* ; Peters, A.

Subclinical disease burden as assessed by whole-body MRI in subjects with prediabetes, subjects with diabetes, and normal control subjects from the general population: The KORA-MRI study.

Diabetes 66, 158-169 (2017)
Verlagsversion Forschungsdaten DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Detailed pathophysiological manifestations of early disease in the context of prediabetes are poorly understood. This study aimed to evaluate the extent of early signs of metabolic and cardio-cerebrovascular complications affecting multiple organs in individuals with prediabetes. Subjects without a history of stroke, coronary artery disease, or peripheral artery disease were enrolled in a case-control study nested within the Cooperative Health Research in the Region of Augsburg (KORA) FF4 cohort and underwent comprehensive MRI assessment to characterize cerebral parameters (white matter lesions, microbleeds), cardiovascular parameters (carotid plaque, left ventricular function, and myocardial late gadolinium enhancement [LGE]), and metabolic parameters (hepatic proton-density fat fraction [PDFF] and subcutaneous and visceral abdominal fat). Among 400 subjects who underwent MRI, 103 subjects had prediabetes and 54 had established diabetes. Subjects with prediabetes had an increased risk for carotid plaque and adverse functional cardiac parameters, including reduced early diastolic filling rates as well as a higher prevalence of LGE compared with healthy control subjects. In addition, people with prediabetes had significantly elevated levels of PDFF and total and visceral fat. Thus, subjects with prediabetes show early signs of subclinical disease that include vascular, cardiac, and metabolic changes, as measured by whole-body MRI after adjusting for cardiometabolic risk factors.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Impaired Fasting Glucose; Cardiovascular Magnetic-resonance; Myocardial-infarction; Insulin-resistance; Diastolic Function; Metabolic Syndrome; Risk-factors; Heart; Prevalence; Radiomics
Sprache englisch
Veröffentlichungsjahr 2017
Prepublished im Jahr 2016
HGF-Berichtsjahr 2016
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Zeitschrift Diabetes
Quellenangaben Band: 66, Heft: 1, Seiten: 158-169 Artikelnummer: , Supplement: ,
Verlag American Diabetes Association
Verlagsort Alexandria, VA.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
90000 - German Center for Diabetes Research
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-006
G-501900-401
G-504090-001
DOI 10.2337/db16-0630
WOS ID WOS:000390834300020
Scopus ID 85007326943
Erfassungsdatum 2016-12-31
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