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Stanelle-Bertram, S.* ; Walendy-Gnirß, K.* ; Speiseder, T.* ; Thiele, S.* ; Asante, I.A.* ; Dreier, C.* ; Kouassi, N.M.* ; Preuß, A.* ; Pilnitz-Stolze, G.* ; Müller, U.* ; Thanisch, S.* ; Richter, M.* ; Scharrenberg, R.* ; Kraus, V.* ; Dörk, R.* ; Schau, L.* ; Herder, V.* ; Gerhauser, I.* ; Pfankuche, V.M.* ; Käufer, C.* ; Waltl, I.* ; Moraes, T.* ; Sellau, J.* ; Hoenow, S.* ; Schmidt-Chanasit, J.* ; Jansen, S.* ; Schattling, B.* ; Ittrich, H.* ; Bartsch, U.* ; Renné, T.* ; Bartenschlager, R.* ; Arck, P.* ; Cadar, D.* ; Friese, M.A.* ; Vapalahti, O.* ; Lotter, H.* ; Benites, S.* ; Rolling, L.* ; Gabriel, M.* ; Baumgärtner, W.* ; Morellini, F.* ; Hölter, S.M. ; Amarie, O.V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Löscher, W.* ; Calderon de Anda, F.* ; Gabriel, G.*

Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood.

Nat. Microbiol. 3, 1161–1174 (2018)
Postprint DOI PMC
Open Access Green
Congenital Zika virus (ZIKV) syndrome may cause fetal microcephaly in -1% of affected newborns. Here, we investigate whether the majority of clinically inapparent newborns might suffer from long-term health impairments not readily visible at birth. Infection of immunocompetent pregnant mice with high-dose ZIKV caused severe offspring phenotypes, such as fetal death, as expected. By contrast, low-dose (LD) maternal ZIKV infection resulted in reduced fetal birth weight but no other obvious phenotypes. Male offspring born to LD ZIKV-infected mothers had increased testosterone (TST) levels and were less likely to survive in utero infection compared to their female littermates. Males also presented an increased number of immature neurons in apical and basal hippocampal dendrites, while female offspring had immature neurons in basal dendrites only. Moreover, male offspring with high but not very high (storm) TST levels were more likely to suffer from learning and memory impairments compared to females. Future studies are required to understand the impact of TST on neuropathological and neurocognitive impairments in later life. In summary, increased sex-specific vigilance is required in countries with high ZIKV prevalence, where impaired neurodevelopment may be camouflaged by a healthy appearance at birth.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Morris Water Maze; Virus-infection; Brain; Testosterone; Pregnancy; Leads; Exposure; Models; Growth; Memory
Sprache
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 2058-5276
e-ISSN 2058-5276
Zeitschrift Nature microbiology
Quellenangaben Band: 3, Heft: 10, Seiten: 1161–1174 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)
Institute of Experimental Genetics (IEG)
POF Topic(s) 30204 - Cell Programming and Repair
30201 - Metabolic Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500500-001
G-500500-002
G-500692-001
G-500600-001
DOI 10.1038/s41564-018-0236-1
WOS ID WOS:000448228400014
Scopus ID 85053500149
PubMed ID 30202017
Erfassungsdatum 2018-09-11
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