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Yang, H. ; Jüstel, D. ; Prakash, J.* ; Karlas, A. ; Helfen, A.* ; Masthoff, M.* ; Wildgruber, M.* ; Ntziachristos, V.

Soft ultrasound priors in optoacoustic reconstruction: Improving clinical vascular imaging.

Photoacoustics 19:100172 (2020)
Postprint Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Using the same ultrasound detector, hybrid optoacoustic-ultrasound (OPUS) imaging provides concurrent scans of tissue slices or volumes and visualizes complementary sound- and light-based contrast at similar resolutions. In addition to the benefit of hybrid contrast, spatial co-registration enables images from one modality to be employed as prior information for improving an aspect of the performance of the other modality. We consider herein a handheld OPUS system and utilize structural information from ultrasound images to guide regional Laplacian regularization-based reconstruction of optoacoustic images. Using phantoms and data from OPUS scans of human radial and carotid arteries, we show that ultrasound-driven optoacoustic inversion reduces limited-view artefacts and improves image contrast. In phantoms, prior-integrated reconstruction leads to a 50 % higher contrast-to-noise ratio (CNR) of the image than standard reconstruction, and a 17 % higher structural similarity (SSIM) index. In clinical data, prior-integrated reconstruction detects deep-seated radial arteries with higher CNR than the standard method at three different depths. In this way, the prior-integrated method offers unique insights into atherosclerotic carotid plaques in humans (with p < 0.01 between patients and healthy volunteers), potentially paving the way for new abilities in vascular imaging and more generally in optoacoustic imaging.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Photoacoustics ; Hybrid Imaging ; Regional Laplacian Regularization ; Carotid ; Radial Artery; Photoacoustic Tomography; Acoustic Inversion; System; Fluorescence; Visibility; Projection; Artifacts
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 2213-5979
Zeitschrift Photoacoustics
Quellenangaben Band: 19, Heft: , Seiten: , Artikelnummer: 100172 Supplement: ,
Verlag Elsevier
Verlagsort Hackerbrucke 6, 80335 Munich, Germany
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505500-001
Förderungen Alexander von Humboldt Postdoctoral Fellowship program
CSC
Deutsche Forschungsgemeinschaft DFG, Germany
European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme
DOI 10.1016/j.pacs.2020.100172
WOS ID WOS:000573285200009
Scopus ID 85082691101
PubMed ID 32280585
Erfassungsdatum 2020-04-15
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