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Bliziotis, N.G.* ; Kluijtmans, L.A.J.* ; Soto, S.* ; Tinnevelt, G.H.* ; Langton, K.* ; Robledo, M.* ; Pamporaki, C.* ; Engelke, U.F.H.* ; Erlic, Z.* ; Engel, J.* ; Deutschbein, T.* ; Nölting, S.* ; Prejbisz, A.* ; Richter, S.* ; Prehn, C. ; Adamski, J. ; Januszewicz, A.* ; Reincke, M.* ; Fassnacht, M.* ; Eisenhofer, G.* ; Beuschlein, F.* ; Kroiss, M.* ; Wevers, R.A.* ; Jansen, J.J.* ; Deinum, J.* ; Timmers, H.J.L.M.* ; Adamski, J.*

Pre- versus post-operative untargeted plasma nuclear magnetic resonance spectroscopy metabolomics of pheochromocytoma and paraganglioma.

Endocrine, DOI: 10.1007/s12020-021-02858-z (2021)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
PURPOSE: Pheochromocytomas and Paragangliomas (PPGL) result in chronic catecholamine excess and serious health complications. A recent study obtained a metabolic signature in plasma from PPGL patients; however, its targeted nature may have generated an incomplete picture and a broader approach could provide additional insights. We aimed to characterize the plasma metabolome of PPGL patients before and after surgery, using an untargeted approach, and to broaden the scope of the investigated metabolic impact of these tumors. DESIGN: A cohort of 36 PPGL patients was investigated. Blood plasma samples were collected before and after surgical tumor removal, in association with clinical and tumor characteristics. METHODS: Plasma samples were analyzed using untargeted nuclear magnetic resonance (NMR) spectroscopy metabolomics. The data were evaluated using a combination of uni- and multi-variate statistical methods. RESULTS: Before surgery, patients with a nonadrenergic tumor could be distinguished from those with an adrenergic tumor based on their metabolic profiles. Tyrosine levels were significantly higher in patients with high compared to those with low BMI. Comparing subgroups of pre-operative samples with their post-operative counterparts, we found a metabolic signature that included ketone bodies, glucose, organic acids, methanol, dimethyl sulfone and amino acids. Three signals with unclear identities were found to be affected. CONCLUSIONS: Our study suggests that the pathways of glucose and ketone body homeostasis are affected in PPGL patients. BMI-related metabolite levels were also found to be altered, potentially linking muscle atrophy to PPGL. At baseline, patient metabolomes could be discriminated based on their catecholamine phenotype.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Metabolomics ; Nmr ; Operation ; Ppgl ; Paired ; Plasma; Norepinephrine; Epinephrine; Metabolism
ISSN (print) / ISBN 1355-008X
e-ISSN 1559-0100
Zeitschrift Endocrine
Verlag Springer
Verlagsort Totowa, NJ
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Experimental Genetics (IEG)
CF Metabolomics & Proteomics (CF-MPC)
Förderungen ENSAT-HT - European Union