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Muhammad, M.H. ; Prakash, J. ; Liapis, E. ; Ntziachristos, V. ; Jüstel, D.

Weighted model-based optoacoustic reconstruction for partial-view geometries.

J. Biophotonics 15:e202100334 (2022)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Acoustic heterogeneities in biological samples are known to cause artefacts in tomographic optoacoustic (photoacoustic) image reconstruction. A statistical weighted model-based reconstruction approach was previously introduced to mitigate such artefacts. However, this approach does not reliably provide high-quality reconstructions for partial-view imaging systems, which are common in preclinical and clinical optoacoustics. In this paper, the capability of the weighted model-based algorithm is extended to generate optoacoustic reconstructions with less distortions for partial-view geometry data. This is achieved by manipulating the weighting scheme based on the detector geometry. Using partial-view optoacoustic tomography data from a tissue-mimicking phantom containing a strong acoustic reflector, tumors grafted onto mice, and a mouse brain with intact skull, the proposed partial-view-corrected weighted model-based algorithm is shown to mitigate reflection artefacts in reconstructed images without distorting structures or boundaries, compared to both conventional model-based and the weighted model-based algorithms. It is also demonstrated that the partial-view-corrected weighted model-based algorithm has the additional advantage of suppressing streaking artefacts due to the partial-view geometry itself in the presence of a very strong optoacoustic chromophore. Due to its enhanced performance, the partial-view-corrected weighted model-based algorithm may prove useful for improving the quality of partial-view multispectral optoacoustic tomography, leading to enhanced visualization of functional parameters such as tissue oxygenation. This article is protected by copyright. All rights reserved.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Acoustic Heterogeneities ; Optoacoustic (photoacoustic) Imaging ; Partial-view Correction ; Streaking Artefacts ; Weighted Model-based Reconstruction; Image-reconstruction; Tomography
ISSN (print) / ISBN 1864-063X
e-ISSN 1864-0648
Zeitschrift Journal of Biophotonics
Quellenangaben Band: 15, Heft: 6, Seiten: , Artikelnummer: e202100334 Supplement: ,
Verlag Wiley
Verlagsort Postfach 101161, 69451 Weinheim, Germany
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
Institute of Computational Biology (ICB)
Förderungen Horizon 2020 Framework Programme
FP7 People: Marie-Curie Actions
Alexander von Humboldt-Stiftung