Philipps, M.* ; Körner, A.* ; Vanhoefer, J.* ; Pathirana, D.* ; Hasenauer, J.
Non-negative universal differential equations with applications in systems biology.
In: (10th IFAC Conference on Foundations of Systems Biology in Engineering, FOSBE 2024, 8-11 September 2024, Corfu Island). Frankfurt ; München [u.a.]: Elsevier, 2024. 25-30 (IFAC PapersOnline ; 58)
Universal differential equations (UDEs) leverage the respective advantages of mechanistic models and artificial neural networks and combine them into one dynamic model. However, these hybrid models can suffer from unrealistic solutions, such as negative values for biochemical quantities. We present non-negative UDE (nUDEs), a constrained UDE variant that guarantees non-negative values. Furthermore, we explore regularisation techniques to improve generalisation and interpretability of UDEs.
Impact Factor
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Times Cited
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Publikationstyp
Artikel: Konferenzbeitrag
Dokumenttyp
Typ der Hochschulschrift
Herausgeber
Schlagwörter
Kinetic Modelling And Control Of Biological Systems ; Neural Networks ; Parameter And State Estimation ; Parametric Optimization ; Systems Biology; Networks
Keywords plus
Sprache
englisch
Veröffentlichungsjahr
2024
Prepublished im Jahr
0
HGF-Berichtsjahr
2024
ISSN (print) / ISBN
2405-8963
e-ISSN
1474-6670
ISBN
Bandtitel
Konferenztitel
10th IFAC Conference on Foundations of Systems Biology in Engineering, FOSBE 2024
Konferzenzdatum
8-11 September 2024
Konferenzort
Corfu Island
Konferenzband
Quellenangaben
Band: 58,
Heft: 23,
Seiten: 25-30
Artikelnummer: ,
Supplement: ,
Reihe
Verlag
Elsevier
Verlagsort
Frankfurt ; München [u.a.]
Tag d. mündl. Prüfung
0000-00-00
Betreuer
Gutachter
Prüfer
Topic
Hochschule
Hochschulort
Fakultät
Veröffentlichungsdatum
0000-00-00
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
Anmeldeland
Priorität
Begutachtungsstatus
Peer reviewed
POF Topic(s)
30205 - Bioengineering and Digital Health
Forschungsfeld(er)
Enabling and Novel Technologies
PSP-Element(e)
G-553800-001
Förderungen
University of Bonn
German Federal Ministry of Education and Research (BMBF) under the CompLS program (GENImmune)
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy
Copyright
Erfassungsdatum
2024-11-19