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Ritzel, K.* ; Fedtke, V.* ; Then, C.* ; Nowak, E.* ; Vogel, F.* ; Braun, L.* ; Zopp, S.* ; Zimmermann, P.* ; Peters, A. ; Heier, M. ; Linkohr, B. ; Roden, M.* ; Bidlingmaier, M.* ; Beuschlein, F.* ; Reincke, M.* ; Rubinstein, G.*

Hypertension and kidney dysfunction despite long-term remission of Cushing's syndrome.

J. Endocrinol. Invest., 11 (2025)
Postprint Forschungsdaten DOI PMC
Open Access Green
PURPOSE: Hypertension is the most frequent co-morbidity in active Cushing's syndrome (CS) and regarded as a major cardio-vascular risk factor. It is unknown whether blood pressure and related parameters, such as kidney function, recover in the long-term following remission of CS. METHODS: Blood pressure and related co-morbidities were analyzed in a cohort of 81 patients with CS (Cushing's disease: 52, ectopic CS: 8, adrenal CS: 21) from a single tertiary care center. Patients were longitudinally evaluated at baseline, at 7.1 years (6.3-7.4) and at 14 years (13.5-14.4) after biochemical remission. Data were compared to a control group matched for BMI, age and sex (n = 243) from the "Cooperative Health Research in the Region of Augsburg" study (KORA) in a 1:3 fashion. RESULTS: Patients with CS showed a higher median blood pressure and lower median glomerular filtration rate (GFR) compared to the matched controls, at baseline, 7 and 14 years after biochemical remission. Although the prevalence of hypertension and chronic kidney disease increased over time in the KORA cohort, patients treated for CS had a significantly higher prevalence of both comorbidities. Notably, the number of patients on antihypertensive medication declined in the Cushing's cohort, resulting in significantly higher rates of uncontrolled hypertension at follow-up. CONCLUSION: The prevalence of hypertension and impaired kidney function remained elevated in patients with CS years after biochemical remission, potentially contributing to an unfavorable long-term clinical outcome. This highlights the critical need for increased monitoring and treatment of co-morbidities in patients with CS following surgical remission.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Blood Pressure ; Co-morbidities ; Cushing’s Syndrome ; Hypertension ; Kidney Function ; Remission; Blood-pressure; Risk-factors; Disease; Hypercortisolism; Hydrocortisone
ISSN (print) / ISBN 0391-4097
e-ISSN 1720-8386
Zeitschrift Journal of Endocrinological Investigation
Quellenangaben Band: , Heft: , Seiten: 11 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort One New York Plaza, Suite 4600, New York, Ny, United States
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Förderungen Else Kroner-Fresenius Stiftung
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
Munich Clinician Scientist Program (MCSP) of the LMU Munche
Clinician Scientist Program RISE (Rare Important Syndromes in Endocrinology)
Eva Luise und Horst Kohler Stiftung
Helmholtz Zentrum Munchen-German Research Center for Environmental Health
German Federal Ministry of Education and Research (BMBF)
State of Bavaria
Munich Center of Health Sciences (MC Health), Ludwig-Maximilians-Universitat, as part of LMUinnovativ
German Federal Ministry of Education and Research (BMBF) as part of the 'Health in old age' program
Bavarian State Ministry of Health and Care through the research project DigiMed Bayern
DZHK (German Centre for Cardiovascular Research)
BMBF (German Ministry of Education and Research)