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Alter, P.* ; Watz, H.* ; Kahnert, K.* ; Pfeifer, M.* ; Randerath, W.J.* ; Andreas, S.* ; Waschki, B.* ; Kleibrink, B.E.* ; Welte, T.* ; Bals, R.* ; Schulz, H. ; Biertz, F.* ; Young, D.M.* ; Vogelmeier, C.F.* ; Jörres, R.A.*

Airway obstruction and lung hyperinflation in COPD are linked to an impaired left ventricular diastolic filling.

Respir. Med. 137, 14-22 (2018)
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Aims: Chronic obstructive pulmonary disease (COPD) and cardiovascular diseases are thought to be linked through various factors. We aimed to assess the relationship between airway obstruction, lung hyperinflation and diastolic filling in COPD. Methods: The study population was a subset of the COPD cohort COSYCONET. Echocardiographic parameters included the left atrial diameter (LA), early (E) and late (A) transmitral flow, mitral annulus velocity (e'), E wave deceleration time (E[dt]), and isovolumic relaxation time (IVRT). We quantified the effect of various predictors including forced expiratory volume in 1 s (FEV1) and intrathoracic gas volume (ITGV) on the echocardiographic parameters by multiple linear regression and integrated the relationships into a path analysis model. Results: A total of 615 COPD patients were included (mean FEV1 52.6% predicted). In addition to influences of age, BMI and blood pressure, ITGV was positively related to e'-septal and negatively to LA, FEV1 positively to E(dt) (p < 0.05 each). The effect of predictors was most pronounced for LA, e'-septal and E(dt), and less for E/A, IVRT and E/e'. Path analysis was used to take into account the additional relationships between the echocardiographic parameters themselves, demonstrating that their associations with the predictors were maintained and robust. Conclusions: Airway obstruction and lung hyperinflation were significantly associated with cardiac diastolic filling in patients with COPD, suggesting a decreased preload rather than an inherently impaired myocardial relaxation itself. This suggests that a reduction in obstruction and hyperinflation could help to improve cardiac filling.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Copd ; Airway Obstruction ; Hyperinflation ; Diastolic Filling ; Dyspnea ; Heart Failure ; Hfpef; Preserved Ejection Fraction; Decompensated Heart-failure; Late Gadolinium Enhancement; Pulmonary-disease; Wall Stress; Myocardial-infarction; Inflammatory Markers; Base-line; Impact; Dysfunction
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 0954-6111
e-ISSN 1532-3064
Journal Respiratory Medicine
Quellenangaben Volume: 137, Issue: , Pages: 14-22 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
80000 - German Center for Lung Research
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-009
G-501810-004
DOI 10.1016/j.rmed.2018.02.011
WOS ID WOS:000428794100003
Scopus ID 85042368801
PubMed ID 29605197
Erfassungsdatum 2018-05-17
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