PuSH - Publication Server of Helmholtz Zentrum München: Myeloperoxidase, superoxide dismutase-3, cardiometabolic risk factors, and distal sensorimotor polyneuropathy: The KORA F4/FF4 study.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Herder, C.* ; Kannenberg, J.M.* ; Huth, C. ; Carstensen-Kirberg, M.* ; Rathmann, W.* ; Koenig, W.* ; Strom, A.* ; Bönhof, G.J.* ; Heier, M. ; Thorand, B. ; Peters, A. ; Roden, M.* ; Meisinger, C. ; Ziegler, D.*

Myeloperoxidase, superoxide dismutase-3, cardiometabolic risk factors, and distal sensorimotor polyneuropathy: The KORA F4/FF4 study.

Diabetes Metab. Res. Rev. 34:e3000 (2018)

Postprint

DOI

PMC

	Open Access Green

Abstract
Metrics
Extra information

BackgroundOxidative stress has been proposed as important pathomechanism of cardiometabolic diseases and distal sensorimotor polyneuropathy (DSPN). However, the relevance of biomarkers of oxidative stress has not been investigated in this context. Therefore, this study aimed to assess the association of the prooxidant myeloperoxidase (MPO) and the antioxidant extracellular superoxide dismutase (SOD3) with cardiometabolic risk factors and with prevalence and incidence of DSPN.MethodsCross-sectional analyses comprised 1069 participants (40.3% with prediabetes and 20.5% with type 2 diabetes) of the population-based Cooperative Health Research in the Region of Augsburg (KORA) F4 study (2006-2008), 181 of whom had DSPN at baseline. Prospective analyses included 524 individuals without DSPN at baseline who also participated in the KORA FF4 study (2013-2014), 132 of whom developed DSPN during the 6.5-year follow-up. Serum MPO and SOD3 were measured by ELISA, and their association with cardiometabolic risk factors and DSPN were estimated by using linear and logistic regression analyses.ResultsHigher MPO and SOD levels showed multiple positive associations with cardiometabolic risk factors including age, indices of obesity, insulin resistance, serum lipids, renal dysfunction, and biomarkers of inflammation. Higher MPO levels were associated with prevalent DSPN (fully adjusted OR 1.38 [95% CI 1.10; 1.72] per doubling of MPO). Higher baseline SOD3 levels were related to incident DSPN (age and sex-adjusted OR 2.14 [1.02; 4.48] per doubling of SOD3), which was partially explained by cardiometabolic risk factors.ConclusionsSystemic levels of both pro- and antioxidant enzymes appear involved in cardiometabolic risk and development of DSPN.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Cardiovascular Risk Factors ; Myeloperoxidase ; Neuropathy ; Oxidative Stress ; Polyneuropathy ; Superoxide Dismutase; Cardiovascular Autonomic Neuropathy; Coronary-artery-disease; Diabetic-neuropathy; Subclinical Inflammation; Oxidative Stress; Serum-levels; Population; Association; Antagonist; F4

ISSN (print) / ISBN 1520-7552

e-ISSN 1520-7560

Journal Diabetes/Metabolism Research and Reviews

Quellenangaben Volume: 34, Issue: 5, Article Number: e3000

Publisher Wiley

Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology II (EPI2)