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McGuinn, L.A.* ; Schneider, A.E. ; McGarrah, R.W.* ; Ward-Caviness, C.* ; Neas, L.M.* ; Di, Q.* ; Schwartz, J.* ; Hauser, E.R.* ; Kraus, W.E.* ; Cascio, W.E.* ; Diaz-Sanchez, D.* ; Devlin, R.B.*

Association of long-term PM2.5 exposure with traditional and novel lipid measures related to cardiovascular disease risk.

Environ. Int. 122, 193-200 (2019)
Publ. Version/Full Text Postprint DOI PMC
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Background: Fine particulate matter (PM2.5) exposure is associated with increased morbidity and mortality, particularly for cardiovascular disease. The association between long-term exposure to PM2.5 and measures of lipoprotein subfractions remains unclear. Therefore, we examined associations between long-term PM2.5 exposure and traditional and novel lipoprotein measures in a cardiac catheterization cohort in North Carolina.Methods: This cross-sectional study included 6587 patients who had visited Duke University for a cardiac catheterization between 2001 and 2010 and resided in North Carolina. We used estimates of daily PM2.5 concentrations on a 1 km-grid based on satellite measurements. PM2.5 predictions were matched to the address of each patient and averaged for the year prior to catheterization date. Serum lipids included HDL, LDL, and triglyceride-rich particle, and apolipoprotein B concentrations (HDL-P, LDL-P, TRL-P, and apoB, respectively). Linear and quantile regression models were used to estimate change in lipoprotein levels with each mu g/m(3) increase in annual average PM2.5. Models were adjusted for age, sex, race/ethnicity, history of smoking, area-level education, urban/rural status, body mass index, and diabetes.Results: For a 1-mu g/m(3) increment in PM2.5 exposure, we observed increases in total and small LDL-P, LDL-C, TRLP, apoB, total cholesterol, and triglycerides. The percent change from the mean outcome level was 2.00% (95% CI: 1.38%, 2.64%) for total LDL-P and 2.25% (95% CI: 1.43%, 3.06%) for small LDL-P.Conclusion: Among this sample of cardiac catheterization patients residing in North Carolina, long-term PM2.5 exposure was associated with increases in several lipoprotein concentrations. This abstract does not necessarily reflect U.S. EPA policy.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Fine Particulate Matter ; Lipids ; Cardiovascular Disease ; Air Pollution; Lipoprotein Particle Concentration; Magnetic-resonance Spectroscopy; Air-pollution Exposure; Coronary-heart-disease; Particulate Matter; Atherosclerosis; Cholesterol; Number; Size; Biomarkers
Language english
Publication Year 2019
Prepublished in Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 0160-4120
e-ISSN 1873-6750
Journal Environment International
Quellenangaben Volume: 122, Issue: , Pages: 193-200 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-001
DOI 10.1016/j.envint.2018.11.001
WOS ID WOS:000454356400017
Scopus ID 85056338795
PubMed ID 30446244
Erfassungsdatum 2018-11-22
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