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Shrine, N.* ; Guyatt, A.L.* ; Erzurumluoglu, A.M.* ; Jackson, V.E.* ; Hobbs, B.D.* ; Melbourne, C.A.* ; Batini, C.* ; Fawcett, K.A.* ; Song, K.* ; Sakornsakolpat, P.* ; Li, X.* ; Boxall, R.* ; Reeve, N.F.* ; Obeidat, M.* ; Zhao, J.H.* ; Wielscher, M.* ; Weiss, S.* ; Kentistou, K.A.* ; Cook, J.P.* ; Sun, B.B.* ; Zhou, J.* ; Hui, J.* ; Karrasch, S. ; Imboden, M.* ; Harris, S.E.* ; Marten, J.* ; Enroth, S.* ; Kerr, S.M.* ; Surakka, I.* ; Vitart, V.* ; Lehtimäki, T.* ; Allen, R.J.* ; Bakke, P.S.* ; Beaty, T.H.* ; Bleecker, E.R.* ; Bossé, Y.* ; Brandsma, C.A.* ; Chen, Z.* ; Crapo, J.D.* ; Danesh, J.* ; DeMeo, D.L.* ; Dudbridge, F.* ; Ewert, R.* ; Gieger, C. ; Gulsvik, A.* ; Hansell, A.L.* ; Hao, K.* ; Hoffman, J.D.* ; Hokanson, J.E.* ; Homuth, G.* ; Joshi, P.K.* ; Joubert, P.* ; Langenberg, C.* ; Li, L.* ; Lin, K.* ; Lind, L.* ; Locantore, N.* ; Luan, J.* ; Mahajan, A.* ; Maranville, J.C.* ; Murray, A.* ; Nickle, D.C.* ; Packer, R.* ; Parker, M.M.* ; Paynton, M.L.* ; Porteous, D.J.* ; Prokopenko, D.* ; Qiao, D.* ; Rawal, R. ; Runz, H.* ; Sayers, I.* ; Sin, D.D.* ; Smith, B.H.* ; Soler Artigas, M.* ; Sparrow, D.* ; Tal-Singer, R.* ; Timmers, P.R.H.J.* ; van den Berge, M.* ; Whittaker, J.C.* ; Woodruff, P.G.* ; Yerges-Armstrong, L.M.* ; Troyanskaya, O.G.* ; Raitakari, O.T.* ; Kähönen, M.* ; Polašek, O.* ; Gyllensten, U.* ; Rudan, I.* ; Deary, I.J.* ; Probst-Hensch, N.M.* ; Schulz, H. ; James, A.L.* ; Wilson, J.F.* ; Stubbe, B.* ; Zeggini, E. ; Jarvelin, M.R.* ; Wareham, N.J.* ; Silverman, E.K.* ; Hayward, C.* ; Morris, A.P.* ; Butterworth, A.S.* ; Scott, R.A.* ; Walters, R.G.* ; Meyers, D.A.* ; Cho, M.H.* ; Strachan, D.P.* ; Hall, I.P.* ; Tobin, M.D.* ; Wain, L.V.*

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Nat. Genet. 51, 481-493 (2019)
Postprint DOI PMC
Open Access Green
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in independent populations. Furthermore, the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups. We highlight biological pathways, known and potential drug targets for COPD and, in phenome-wide association studies, autoimmune-related and other pleiotropic effects of lung function-associated variants. This new genetic evidence has potential to improve future preventive and therapeutic strategies for COPD.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Genome-wide Association; Loci; Gwas; Heritability; Variants; Copd
Language english
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 51, Issue: 3, Pages: 481-493 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Translational Genomics (ITG)
POF-Topic(s) 30202 - Environmental Health
30205 - Bioengineering and Digital Health
80000 - German Center for Lung Research
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-009
G-504091-004
G-506700-001
G-501800-401
DOI 10.1038/s41588-018-0321-7
WOS ID WOS:000459947200016
Scopus ID 85062074587
PubMed ID 30804560
Erfassungsdatum 2019-03-19
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