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Teckentrup, V.* ; Neubert, S.* ; Santiago, J.C. ; Hallschmid, M. ; Walter, M.* ; Kroemer, N.B.*

Non-invasive stimulation of vagal afferents reduces gastric frequency.

Brain Stimul. 13, 470-473 (2020)
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Metabolic feedback between the gut and the brain relayed via the vagus nerve contributes to energy homeostasis. We investigated in healthy adults whether non-invasive stimulation of vagal afferents impacts energy homeostasis via efferent effects on metabolism or digestion. In a randomized crossover design, we applied transcutaneous auricular vagus nerve stimulation (taVNS) while recording efferent metabolic effects using simultaneous electrogastrography (EGG) and indirect calorimetry. We found that taVNS reduced gastric myoelectric frequency (p = .008), but did not alter resting energy expenditure. We conclude that stimulating vagal afferents induces gastric slowing via vagal efferents without acutely affecting net energy expenditure at rest. Collectively, this highlights the potential of taVNS to modulate digestion by activating the dorsal vagal complex. Thus, taVNS-induced changes in gastric frequency are an important peripheral marker of brain stimulation effects.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Transcutaneous Auricular Vagus Nerve Stimulation ; Tavns ; Electrogastrogram ; Resting Energy Expenditure ; Energy Homeostasis; Vagus Nerve-stimulation; Brain-stem; Dopamine; Vagotomy
Language
Publication Year 2020
Prepublished in Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 1935-861X
e-ISSN 1876-4754
Journal Brain stimulation
Quellenangaben Volume: 13, Issue: 2, Pages: 470-473 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502400-001
DOI 10.1016/j.brs.2019.12.018
WOS ID WOS:000509471600037
Scopus ID 85077010051
PubMed ID 31884186
Erfassungsdatum 2020-01-14
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