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Non-invasive stimulation of vagal afferents reduces gastric frequency.
Brain Stimul. 13, 470-473 (2020)
Publ. Version/Full Text
Research data
DOI
PMC
Metabolic feedback between the gut and the brain relayed via the vagus nerve contributes to energy homeostasis. We investigated in healthy adults whether non-invasive stimulation of vagal afferents impacts energy homeostasis via efferent effects on metabolism or digestion. In a randomized crossover design, we applied transcutaneous auricular vagus nerve stimulation (taVNS) while recording efferent metabolic effects using simultaneous electrogastrography (EGG) and indirect calorimetry. We found that taVNS reduced gastric myoelectric frequency (p = .008), but did not alter resting energy expenditure. We conclude that stimulating vagal afferents induces gastric slowing via vagal efferents without acutely affecting net energy expenditure at rest. Collectively, this highlights the potential of taVNS to modulate digestion by activating the dorsal vagal complex. Thus, taVNS-induced changes in gastric frequency are an important peripheral marker of brain stimulation effects.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Transcutaneous Auricular Vagus Nerve Stimulation ; Tavns ; Electrogastrogram ; Resting Energy Expenditure ; Energy Homeostasis; Vagus Nerve-stimulation; Brain-stem; Dopamine; Vagotomy
ISSN (print) / ISBN
1935-861X
e-ISSN
1876-4754
Journal
Brain stimulation
Quellenangaben
Volume: 13,
Issue: 2,
Pages: 470-473
Publisher
Elsevier
Publishing Place
New York, NY
Non-patent literature
Publications
Reviewing status
Peer reviewed