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Stiel, A.-C. ; Ntziachristos, V.

Controlling the sound of light: photoswitching optoacoustic imaging.

Nat. Methods 21, 1996-2007 (2024)
Postprint DOI PMC
Open Access Green
Optoacoustic (photoacoustic) imaging advances allow high-resolution optical imaging much deeper than optical microscopy. However, while label-free optoacoustics have already entered clinical application, biological imaging is in need of ubiquitous optoacoustic labels for use in ways that are similar to how fluorescent proteins propelled optical microscopy. We review photoswitching advances that shine a new light or, in analogy, 'bring a new sound' to biological optoacoustic imaging. Based on engineered labels and novel devices, switching uses light or other energy forms and enables signal modulation and synchronous detection for maximizing contrast and detection sensitivity over other optoacoustic labels. Herein, we explain contrast enhancement in the spectral versus temporal domains and review labels and key concepts of switching and their properties to modulate optoacoustic signals. We further outline systems and applications and discuss how switching can enable optoacoustic imaging of cellular or molecular contrast at depths and resolutions beyond those of other optical methods.
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Publication type Article: Journal article
Document type Review
Keywords Infrared Fluorescent Proteins; Deep Tissue; Tomography; Microscopy; Mesoscopy
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 1548-7091
e-ISSN 1548-7105
Journal Nature Methods
Quellenangaben Volume: 21, Issue: 11, Pages: 1996-2007 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505500-001
G-505591-004
Grants European Research Council (ERC)
Deutsche Forschungsgemeinschaft
European Union
DOI 10.1038/s41592-024-02396-2
WOS ID 001413164200002
WOS ID 001319511300002
Scopus ID 85204778738
PubMed ID 39322752
Erfassungsdatum 2024-10-15
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