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Kullmann, S. ; Wagner, L. ; Hauffe, R.* ; Kühnel, A.* ; Sandforth, L. ; Veit, R. ; Dannecker, C. ; Machann, J. ; Fritsche, A. ; Stefan, N. ; Preissl, H. ; Kroemer, N.B.* ; Heni, M.* ; Kleinridders, A.* ; Birkenfeld, A.L.

A short-term, high-caloric diet has prolonged effects on brain insulin action in men.

Nat. Metab. 7, 469-477 (2025)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution. Here we show that short-term overeating with calorie-rich sweet and fatty foods triggers liver fat accumulation and disrupted brain insulin action that outlasted the time-frame of its consumption in healthy weight men. Hence, brain response to insulin can adapt to short-term changes in diet before weight gain and may facilitate the development of obesity and associated diseases.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Alzheimers-disease; Adipose-tissue; Reward; Sensitivity; Resistance; Inflammation; Version; Go
ISSN (print) / ISBN 2522-5812
e-ISSN 2522-5812
Journal Nature metabolism
Quellenangaben Volume: 7, Issue: 3, Pages: 469-477 Article Number: , Supplement: ,
Publisher Springer
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
Grants Federal Ministry of Education and Research
Bundesministerium fr Bildung und Forschung (Federal Ministry of Education and Research)