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Kullmann, S. ; Wagner, L. ; Hauffe, R.* ; Kühnel, A.* ; Sandforth, L. ; Veit, R. ; Dannecker, C. ; Machann, J. ; Fritsche, A. ; Stefan, N. ; Preissl, H. ; Kroemer, N.B.* ; Heni, M.* ; Kleinridders, A.* ; Birkenfeld, A.L.

A short-term, high-caloric diet has prolonged effects on brain insulin action in men.

Nat. Metab. 7, 469-477 (2025)
Publ. Version/Full Text Research data DOI PMC
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Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution. Here we show that short-term overeating with calorie-rich sweet and fatty foods triggers liver fat accumulation and disrupted brain insulin action that outlasted the time-frame of its consumption in healthy weight men. Hence, brain response to insulin can adapt to short-term changes in diet before weight gain and may facilitate the development of obesity and associated diseases.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Alzheimers-disease; Adipose-tissue; Reward; Sensitivity; Resistance; Inflammation; Version; Go
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 2522-5812
e-ISSN 2522-5812
Journal Nature metabolism
Quellenangaben Volume: 7, Issue: 3, Pages: 469-477 Article Number: , Supplement: ,
Publisher Springer
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502400-001
Grants Federal Ministry of Education and Research
Bundesministerium fr Bildung und Forschung (Federal Ministry of Education and Research)
DOI 10.1038/s42255-025-01226-9
WOS ID 001454471800001
Scopus ID 85218702028
PubMed ID 39984682
Erfassungsdatum 2025-04-15
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